BRD-K64642496_-666_HEPG2_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K64642496_-666_HEPG2_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AXIN1 axin 1
BEX4 brain expressed, X-linked 4
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLCA4 chloride channel accessory 4
CLDN3 claudin 3
CRISP3 cysteine-rich secretory protein 3
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT4 DNA-damage-inducible transcript 4
DUOX2 dual oxidase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GSE1 Gse1 coiled-coil protein
HAPLN1 hyaluronan and proteoglycan link protein 1
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
LCN2 lipocalin 2
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MMP2 matrix metallopeptidase 2
MTSS1 metastasis suppressor 1
MYO1D myosin ID
NCAPD2 non-SMC condensin I complex, subunit D2
NMU neuromedin U
NQO2 NAD(P)H dehydrogenase, quinone 2
NRCAM neuronal cell adhesion molecule
OLFM4 olfactomedin 4
ORC1 origin recognition complex, subunit 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDZRN3 PDZ domain containing ring finger 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKP2 plakophilin 2
RAD23B RAD23 homolog B (S. cerevisiae)
RAI14 retinoic acid induced 14
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SCN3A sodium channel, voltage gated, type III alpha subunit
SERINC5 serine incorporator 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AQP4 aquaporin 4
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BASP1 brain abundant, membrane attached signal protein 1
C1S complement component 1, s subcomponent
C4BPA complement component 4 binding protein, alpha
C6ORF62 chromosome 6 open reading frame 62
CAST calpastatin
CD59 CD59 molecule, complement regulatory protein
CLTC clathrin, heavy chain (Hc)
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HOPX HOP homeobox
HP haptoglobin
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
LAPTM4B lysosomal protein transmembrane 4 beta
LPL lipoprotein lipase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MXRA7 matrix-remodelling associated 7
NUP62 nucleoporin 62kDa
PAM peptidylglycine alpha-amidating monooxygenase
PCDH9 protocadherin 9
PGAM1 phosphoglycerate mutase 1 (brain)
PGC progastricsin (pepsinogen C)
PLS3 plastin 3
QDPR quinoid dihydropteridine reductase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
S100A10 S100 calcium binding protein A10
SAMD4A sterile alpha motif domain containing 4A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
SORBS3 sorbin and SH3 domain containing 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TIMP4 TIMP metallopeptidase inhibitor 4
TM4SF1 transmembrane 4 L six family member 1
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TXNDC9 thioredoxin domain containing 9
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon