BRD-K64606589_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K64606589_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD3 abhydrolase domain containing 3
ACAA1 acetyl-CoA acyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ADA adenosine deaminase
ADRB2 adrenoceptor beta 2, surface
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCYL2 adenosylhomocysteinase-like 2
ALOX5 arachidonate 5-lipoxygenase
ANOS1 anosmin 1
APOB apolipoprotein B
APOC1 apolipoprotein C-I
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
ARHGAP25 Rho GTPase activating protein 25
ARHGAP32 Rho GTPase activating protein 32
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASPN asporin
BAMBI BMP and activin membrane-bound inhibitor
BZW2 basic leucine zipper and W2 domains 2
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFD complement factor D (adipsin)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CTSH cathepsin H
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSE dermatan sulfate epimerase
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FGL1 fibrinogen-like 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FRY furry homolog (Drosophila)
FYB FYN binding protein
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLRX glutaredoxin (thioltransferase)
GMCL1 germ cell-less, spermatogenesis associated 1
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HPCAL1 hippocalcin-like 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IGSF3 immunoglobulin superfamily, member 3
IGSF6 immunoglobulin superfamily, member 6
IL17RB interleukin 17 receptor B
IL1RN interleukin 1 receptor antagonist
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
ITM2A integral membrane protein 2A
JAG1 jagged 1
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KIF1A kinesin family member 1A
LGMN legumain
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPIN1 lipin 1
LYZ lysozyme
MAGEB2 melanoma antigen family B2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCOLN1 mucolipin 1
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYO1B myosin IB
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG3 paternally expressed 3
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
PRSS2 protease, serine, 2 (trypsin 2)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD51C RAD51 paralog C
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SEPT6 septin 6
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMYD3 SET and MYND domain containing 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SST somatostatin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK17A serine/threonine kinase 17a
STX7 syntaxin 7
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARL4A ADP-ribosylation factor-like 4A
ATF1 activating transcription factor 1
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
BID BH3 interacting domain death agonist
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CALB1 calbindin 1, 28kDa
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
DCLK1 doublecortin-like kinase 1
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGFR epidermal growth factor receptor
EMP3 epithelial membrane protein 3
EMX2 empty spiracles homeobox 2
EREG epiregulin
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HAS2 hyaluronan synthase 2
HDGF hepatoma-derived growth factor
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGHD immunoglobulin heavy constant delta
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCTP1 multiple C2 domains, transmembrane 1
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSRA methionine sulfoxide reductase A
MTA1 metastasis associated 1
NBN nibrin
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMI N-myc (and STAT) interactor
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PDLIM4 PDZ and LIM domain 4
PENK proenkephalin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PRR7 proline rich 7 (synaptic)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SOX17 SRY (sex determining region Y)-box 17
SPRY2 sprouty homolog 2 (Drosophila)
SSFA2 sperm specific antigen 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPBG trophoblast glycoprotein
TRIP6 thyroid hormone receptor interactor 6
TSKU tsukushi, small leucine rich proteoglycan
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZBTB38 zinc finger and BTB domain containing 38
ZIC1 Zic family member 1
ZYX zyxin