BRD-K64606589_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

162 genes differentially expressed following the BRD-K64606589_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALAS1 5'-aminolevulinate synthase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGAP29 Rho GTPase activating protein 29
ARHGAP32 Rho GTPase activating protein 32
ASS1 argininosuccinate synthase 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIK BCL2-interacting killer (apoptosis-inducing)
BZW2 basic leucine zipper and W2 domains 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND3 cyclin D3
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
CORO1A coronin, actin binding protein, 1A
CTSV cathepsin V
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EAF2 ELL associated factor 2
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR3 fibroblast growth factor receptor 3
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GSN gelsolin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IFNGR1 interferon gamma receptor 1
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
LAPTM5 lysosomal protein transmembrane 5
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MGST3 microsomal glutathione S-transferase 3
MMP1 matrix metallopeptidase 1
MPC1 mitochondrial pyruvate carrier 1
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
NFIL3 nuclear factor, interleukin 3 regulated
NOSIP nitric oxide synthase interacting protein
OLFM4 olfactomedin 4
PADI2 peptidyl arginine deiminase, type II
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS1 plastin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SIK1 salt-inducible kinase 1
SNN stannin
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRGN serglycin
SSBP2 single-stranded DNA binding protein 2
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TYROBP TYRO protein tyrosine kinase binding protein
VAT1 vesicle amine transport 1
WDR47 WD repeat domain 47
WFS1 Wolfram syndrome 1 (wolframin)
WIPF2 WAS/WASL interacting protein family, member 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ATF1 activating transcription factor 1
ATP13A3 ATPase type 13A3
BEX1 brain expressed, X-linked 1
CCNB2 cyclin B2
CCND1 cyclin D1
COMT catechol-O-methyltransferase
CYTIP cytohesin 1 interacting protein
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
GTPBP8 GTP-binding protein 8 (putative)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
IGF1R insulin-like growth factor 1 receptor
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
LOX lysyl oxidase
LRRC41 leucine rich repeat containing 41
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCTP1 multiple C2 domains, transmembrane 1
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
PARVB parvin, beta
PHLDA1 pleckstrin homology-like domain, family A, member 1
RAD23B RAD23 homolog B (S. cerevisiae)
SCRN1 secernin 1
SENP6 SUMO1/sentrin specific peptidase 6
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFBI transforming growth factor, beta-induced, 68kDa
USP22 ubiquitin specific peptidase 22
VCAN versican