BRD-K64517075_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K64517075_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABI1 abl-interactor 1
AGTR1 angiotensin II receptor, type 1
ANKRD10 ankyrin repeat domain 10
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CAPG capping protein (actin filament), gelsolin-like
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFB complement factor B
CHIC2 cysteine-rich hydrophobic domain 2
CLIC1 chloride intracellular channel 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HK2 hexokinase 2
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDS iduronate 2-sulfatase
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
KAZN kazrin, periplakin interacting protein
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
LRRC16A leucine rich repeat containing 16A
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MT1F metallothionein 1F
MT1H metallothionein 1H
MTA1 metastasis associated 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
OSMR oncostatin M receptor
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOD2 superoxide dismutase 2, mitochondrial
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TBX2 T-box 2
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
XBP1 X-box binding protein 1
YME1L1 YME1-like 1 ATPase

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1C3 aldo-keto reductase family 1, member C3
CBR1 carbonyl reductase 1
CELF2 CUGBP, Elav-like family member 2
CHMP6 charged multivesicular body protein 6
CXCL12 chemokine (C-X-C motif) ligand 12
DIDO1 death inducer-obliterator 1
DLD dihydrolipoamide dehydrogenase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM117A family with sequence similarity 117, member A
FBLN1 fibulin 1
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GPR183 G protein-coupled receptor 183
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER2 homer scaffolding protein 2
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RA interleukin 2 receptor, alpha
KLHL9 kelch-like family member 9
MATN2 matrilin 2
MRPL16 mitochondrial ribosomal protein L16
MTSS1 metastasis suppressor 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PDGFD platelet derived growth factor D
POSTN periostin, osteoblast specific factor
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
THBS1 thrombospondin 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TP53I3 tumor protein p53 inducible protein 3
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB6 tubulin, beta 6 class V
TXNDC9 thioredoxin domain containing 9
ZW10 zw10 kinetochore protein