BRD-K64517075_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K64517075_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BIRC3 baculoviral IAP repeat containing 3
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CPVL carboxypeptidase, vitellogenic-like
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
EPRS glutamyl-prolyl-tRNA synthetase
FHL2 four and a half LIM domains 2
FOSL2 FOS-like antigen 2
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
JMJD1C jumonji domain containing 1C
KLHL24 kelch-like family member 24
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSLN mesothelin
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNMT RNA (guanine-7-) methyltransferase
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ISOC1 isochorismatase domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
MREG melanoregulin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRP1 neuropilin 1
PLK1 polo-like kinase 1
PRSS23 protease, serine, 23
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC1 syndecan 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
TMEM14A transmembrane protein 14A
TRIL TLR4 interactor with leucine-rich repeats
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III