BRD-K64366758_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K64366758_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CEP57 centrosomal protein 57kDa
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP4A charged multivesicular body protein 4A
CLEC11A C-type lectin domain family 11, member A
CLIC4 chloride intracellular channel 4
CNIH1 cornichon family AMPA receptor auxiliary protein 1
COL9A3 collagen, type IX, alpha 3
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DXO decapping exoribonuclease
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FKBP10 FK506 binding protein 10, 65 kDa
FN1 fibronectin 1
GCH1 GTP cyclohydrolase 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOT1 glutamic-oxaloacetic transaminase 1, soluble
H1F0 H1 histone family, member 0
HBD hemoglobin, delta
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HP haptoglobin
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
MAGED1 melanoma antigen family D1
MAP7 microtubule-associated protein 7
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NUCB2 nucleobindin 2
PENK proenkephalin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RNF167 ring finger protein 167
S100P S100 calcium binding protein P
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SORBS2 sorbin and SH3 domain containing 2
SST somatostatin
TARP TCR gamma alternate reading frame protein
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TSC22D3 TSC22 domain family, member 3
WARS tryptophanyl-tRNA synthetase
ZFAND1 zinc finger, AN1-type domain 1

decreased expression

Symbol Name
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF5 activating transcription factor 5
AXL AXL receptor tyrosine kinase
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CCDC86 coiled-coil domain containing 86
CD14 CD14 molecule
CD93 CD93 molecule
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CX3CR1 chemokine (C-X3-C motif) receptor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EMP2 epithelial membrane protein 2
FASN fatty acid synthase
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KRT19 keratin 19, type I
MAB21L1 mab-21-like 1 (C. elegans)
MAP2K3 mitogen-activated protein kinase kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MTA1 metastasis associated 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PIP prolactin-induced protein
PRKCD protein kinase C, delta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN3 tetraspanin 3
TYMS thymidylate synthetase
WEE1 WEE1 G2 checkpoint kinase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon