BRD-K64157027_ZD 2079 hydrochloride_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K64157027_ZD 2079 hydrochloride_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4C ADP-ribosylation factor-like 4C
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLNK B-cell linker
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA1 cyclin A1
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CLDN3 claudin 3
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DENND1B DENN/MADD domain containing 1B
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EGFL6 EGF-like-domain, multiple 6
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
EVI2A ecotropic viral integration site 2A
EXPH5 exophilin 5
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FKBP4 FK506 binding protein 4, 59kDa
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
INHBB inhibin, beta B
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KRT81 keratin 81, type II
LAPTM5 lysosomal protein transmembrane 5
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCF2 neutrophil cytosolic factor 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
NVL nuclear VCP-like
PBX3 pre-B-cell leukemia homeobox 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
POSTN periostin, osteoblast specific factor
PRR15L proline rich 15-like
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC1 syndecan 1
SNAI2 snail family zinc finger 2
SRGN serglycin
TDO2 tryptophan 2,3-dioxygenase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TP53I3 tumor protein p53 inducible protein 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ANXA5 annexin A5
APOD apolipoprotein D
ASCL1 achaete-scute family bHLH transcription factor 1
C8ORF4 chromosome 8 open reading frame 4
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHPT1 choline phosphotransferase 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
COL9A3 collagen, type IX, alpha 3
CPVL carboxypeptidase, vitellogenic-like
CST3 cystatin C
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EIF5 eukaryotic translation initiation factor 5
FAM134B family with sequence similarity 134, member B
FBXL12 F-box and leucine-rich repeat protein 12
FOLR1 folate receptor 1 (adult)
GLDC glycine dehydrogenase (decarboxylating)
IL6ST interleukin 6 signal transducer
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KPNB1 karyopherin (importin) beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LTBP3 latent transforming growth factor beta binding protein 3
MCUR1 mitochondrial calcium uniporter regulator 1
NOTCH2NL notch 2 N-terminal like
OLFM1 olfactomedin 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PURA purine-rich element binding protein A
QKI QKI, KH domain containing, RNA binding
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
STOM stomatin
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
UGCG UDP-glucose ceramide glucosyltransferase