BRD-K64052750_gefitinib_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K64052750_gefitinib_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CSRP2 cysteine and glycine-rich protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ELF5 E74-like factor 5 (ets domain transcription factor)
FADS3 fatty acid desaturase 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD2 FXYD domain containing ion transport regulator 2
GNAS GNAS complex locus
GPC3 glypican 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
KAZN kazrin, periplakin interacting protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
KRT7 keratin 7, type II
MSMB microseminoprotein, beta-
NARFL nuclear prelamin A recognition factor-like
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
PFKL phosphofructokinase, liver
PHYH phytanoyl-CoA 2-hydroxylase
PROM1 prominin 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRM protein tyrosine phosphatase, receptor type, M
QPCT glutaminyl-peptide cyclotransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF5 serine/arginine-rich splicing factor 5
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYT17 synaptotagmin XVII
TCTA T-cell leukemia translocation altered
TKT transketolase
TMC5 transmembrane channel-like 5
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5

decreased expression

Symbol Name
CCND1 cyclin D1
CHL1 cell adhesion molecule L1-like
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CTH cystathionine gamma-lyase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HAL histidine ammonia-lyase
HOPX HOP homeobox
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
LEPR leptin receptor
MMD monocyte to macrophage differentiation-associated
MT1E metallothionein 1E
NLGN4X neuroligin 4, X-linked
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRDX2 peroxiredoxin 2
SEPP1 selenoprotein P, plasma, 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
XIST X inactive specific transcript (non-protein coding)