BRD-K63979920_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K63979920_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ASPN asporin
CAST calpastatin
CCND2 cyclin D2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DPYSL3 dihydropyrimidinase-like 3
ESR1 estrogen receptor 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HOMER2 homer scaffolding protein 2
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
ITM2A integral membrane protein 2A
LRRC15 leucine rich repeat containing 15
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPT microtubule-associated protein tau
MDFIC MyoD family inhibitor domain containing
MFAP5 microfibrillar associated protein 5
MN1 meningioma (disrupted in balanced translocation) 1
NPY1R neuropeptide Y receptor Y1
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PLAGL1 pleiomorphic adenoma gene-like 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SPON1 spondin 1, extracellular matrix protein
ST7 suppression of tumorigenicity 7
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THY1 Thy-1 cell surface antigen
TMPRSS3 transmembrane protease, serine 3
TNS3 tensin 3
TRIM2 tripartite motif containing 2
TTC3 tetratricopeptide repeat domain 3
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC6 zinc finger, DHHC-type containing 6

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CLU clusterin
DBN1 drebrin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
FHL1 four and a half LIM domains 1
FXYD2 FXYD domain containing ion transport regulator 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS1 lectin, galactoside-binding, soluble, 1
LPL lipoprotein lipase
MLF1 myeloid leukemia factor 1
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
NNMT nicotinamide N-methyltransferase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRKCZ protein kinase C, zeta
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC35F2 solute carrier family 35, member F2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STXBP2 syntaxin binding protein 2
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1