BRD-K63923597_barasertib_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K63923597_barasertib_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANGPT1 angiopoietin 1
AQP1 aquaporin 1 (Colton blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRYAB crystallin, alpha B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
EGR1 early growth response 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FDXR ferredoxin reductase
FHL1 four and a half LIM domains 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GLS glutaminase
GRIA2 glutamate receptor, ionotropic, AMPA 2
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDOC1 leucine zipper, down-regulated in cancer 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAGEA3 melanoma antigen family A3
MEF2C myocyte enhancer factor 2C
MME membrane metallo-endopeptidase
NARFL nuclear prelamin A recognition factor-like
NINJ1 ninjurin 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRIP1 nuclear receptor interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SESN1 sestrin 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC22A18 solute carrier family 22, member 18
TMEM47 transmembrane protein 47
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSPAN4 tetraspanin 4

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACD adrenocortical dysplasia homolog (mouse)
ANXA3 annexin A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATAD2 ATPase family, AAA domain containing 2
C7 complement component 7
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPN centromere protein N
CENPU centromere protein U
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
EXO1 exonuclease 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAUS3 HAUS augmin-like complex, subunit 3
KCTD12 potassium channel tetramerization domain containing 12
KLHL23 kelch-like family member 23
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
MAPK13 mitogen-activated protein kinase 13
MCM3 minichromosome maintenance complex component 3
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAPG non-SMC condensin I complex, subunit G
PDLIM5 PDZ and LIM domain 5
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
TACSTD2 tumor-associated calcium signal transducer 2
ZKSCAN1 zinc finger with KRAB and SCAN domains 1