BRD-K63913457_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K63913457_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ATG3 autophagy related 3
BCHE butyrylcholinesterase
BLVRB biliverdin reductase B
C1QTNF3 C1q and tumor necrosis factor related protein 3
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKAP4 cytoskeleton-associated protein 4
COL4A5 collagen, type IV, alpha 5
CRYAB crystallin, alpha B
FABP7 fatty acid binding protein 7, brain
FBXL12 F-box and leucine-rich repeat protein 12
FOXG1 forkhead box G1
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTA4 glutathione S-transferase alpha 4
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOPX HOP homeobox
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ISG15 ISG15 ubiquitin-like modifier
LMO4 LIM domain only 4
LYPD3 LY6/PLAUR domain containing 3
MMP11 matrix metallopeptidase 11
PERP PERP, TP53 apoptosis effector
PIH1D1 PIH1 domain containing 1
PITX1 paired-like homeodomain 1
RNF167 ring finger protein 167
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCEL sciellin
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
USP18 ubiquitin specific peptidase 18
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
XAF1 XIAP associated factor 1
XCL1 chemokine (C motif) ligand 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRF5 adhesion G protein-coupled receptor F5
ADGRG2 adhesion G protein-coupled receptor G2
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
CA2 carbonic anhydrase II
CHMP6 charged multivesicular body protein 6
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPE carboxypeptidase E
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
EPS8 epidermal growth factor receptor pathway substrate 8
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
IGF1R insulin-like growth factor 1 receptor
IL1R2 interleukin 1 receptor, type II
ISYNA1 inositol-3-phosphate synthase 1
ITM2C integral membrane protein 2C
KCTD12 potassium channel tetramerization domain containing 12
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MBNL1 muscleblind-like splicing regulator 1
MGP matrix Gla protein
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RPN1 ribophorin I
SDC4 syndecan 4
SNX13 sorting nexin 13
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TRIM2 tripartite motif containing 2
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZFPM2 zinc finger protein, FOG family member 2