BRD-K63828191_Raloxifene hydrochloride_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K63828191_Raloxifene hydrochloride_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOD apolipoprotein D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLNK B-cell linker
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD9 CD9 molecule
CLDN3 claudin 3
DDIT4 DNA-damage-inducible transcript 4
ENSA endosulfine alpha
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS2 fatty acid desaturase 2
FAM63A family with sequence similarity 63, member A
GBP2 guanylate binding protein 2, interferon-inducible
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
ITM2C integral membrane protein 2C
JUP junction plakoglobin
KCTD12 potassium channel tetramerization domain containing 12
KRT20 keratin 20, type I
LXN latexin
MATN2 matrilin 2
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OLFM4 olfactomedin 4
OPTN optineurin
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLIN2 perilipin 2
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F2 solute carrier family 35, member F2
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STON1 stonin 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
VTCN1 V-set domain containing T cell activation inhibitor 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPN centromere protein N
CENPU centromere protein U
CFAP20 cilia and flagella associated protein 20
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGB2 high mobility group box 2
HOXC6 homeobox C6
IGHM immunoglobulin heavy constant mu
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MSLN mesothelin
MT1E metallothionein 1E
ORC6 origin recognition complex, subunit 6
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS23 protease, serine, 23
PTTG1 pituitary tumor-transforming 1
RAB31 RAB31, member RAS oncogene family
RBBP8 retinoblastoma binding protein 8
RNASEH2A ribonuclease H2, subunit A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMC2 structural maintenance of chromosomes 2
SPDL1 spindle apparatus coiled-coil protein 1
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFF3 trefoil factor 3 (intestinal)
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)