BRD-K63828191_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K63828191_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CIB1 calcium and integrin binding 1 (calmyrin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
DDIT4 DNA-damage-inducible transcript 4
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM63A family with sequence similarity 63, member A
GATA2 GATA binding protein 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRN granulin
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYO6 myosin VI
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PCBP2 poly(rC) binding protein 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PRKCD protein kinase C, delta
PRSS8 protease, serine, 8
PVALB parvalbumin
RAP1GAP RAP1 GTPase activating protein
REEP1 receptor accessory protein 1
RNASET2 ribonuclease T2
S100A11 S100 calcium binding protein A11
SCPEP1 serine carboxypeptidase 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMBIM6 transmembrane BAX inhibitor motif containing 6
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TSPYL1 TSPY-like 1
TXNIP thioredoxin interacting protein
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
BTG3 BTG family, member 3
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCND1 cyclin D1
CD200 CD200 molecule
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CEP55 centrosomal protein 55kDa
COL4A6 collagen, type IV, alpha 6
CTSD cathepsin D
DLK1 delta-like 1 homolog (Drosophila)
DOCK4 dedicator of cytokinesis 4
DSCC1 DNA replication and sister chromatid cohesion 1
FEN1 flap structure-specific endonuclease 1
GAB2 GRB2-associated binding protein 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GREB1 growth regulation by estrogen in breast cancer 1
IGFBP4 insulin-like growth factor binding protein 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAPH non-SMC condensin I complex, subunit H
NOLC1 nucleolar and coiled-body phosphoprotein 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG3 paternally expressed 3
PLK1 polo-like kinase 1
POLR1E polymerase (RNA) I polypeptide E, 53kDa
PON3 paraoxonase 3
PRSS23 protease, serine, 23
RAB31 RAB31, member RAS oncogene family
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RRM1 ribonucleotide reductase M1
RUNX3 runt-related transcription factor 3
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIP13 thyroid hormone receptor interactor 13
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
UBE2S ubiquitin-conjugating enzyme E2S
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta