BRD-K63828191_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K63828191_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARMCX6 armadillo repeat containing, X-linked 6
ATF1 activating transcription factor 1
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
C8ORF4 chromosome 8 open reading frame 4
CTSZ cathepsin Z
CXCL5 chemokine (C-X-C motif) ligand 5
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DUSP22 dual specificity phosphatase 22
EGR3 early growth response 3
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EVL Enah/Vasp-like
EXOSC4 exosome component 4
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GRB14 growth factor receptor-bound protein 14
HDAC6 histone deacetylase 6
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
IL13RA1 interleukin 13 receptor, alpha 1
IQGAP2 IQ motif containing GTPase activating protein 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
MSX1 msh homeobox 1
NPC2 Niemann-Pick disease, type C2
PDLIM5 PDZ and LIM domain 5
PEBP1 phosphatidylethanolamine binding protein 1
PKM pyruvate kinase, muscle
PLAC8 placenta-specific 8
PON2 paraoxonase 2
PRAME preferentially expressed antigen in melanoma
PSD3 pleckstrin and Sec7 domain containing 3
RPS11 ribosomal protein S11
SET SET nuclear proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SNF8 SNF8, ESCRT-II complex subunit
SRC SRC proto-oncogene, non-receptor tyrosine kinase
UBL3 ubiquitin-like 3
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
ANPEP alanyl (membrane) aminopeptidase
ANXA2 annexin A2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASCL1 achaete-scute family bHLH transcription factor 1
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
CAV1 caveolin 1, caveolae protein, 22kDa
CCNE2 cyclin E2
CD9 CD9 molecule
CD93 CD93 molecule
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM107A family with sequence similarity 107, member A
FHL1 four and a half LIM domains 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GUSBP11 glucuronidase, beta pseudogene 11
HBB hemoglobin, beta
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
INA internexin neuronal intermediate filament protein, alpha
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LAMA4 laminin, alpha 4
LAPTM5 lysosomal protein transmembrane 5
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MCAM melanoma cell adhesion molecule
MMP2 matrix metallopeptidase 2
MSMB microseminoprotein, beta-
MTERF3 mitochondrial transcription termination factor 3
MZB1 marginal zone B and B1 cell-specific protein
NEBL nebulette
NPIPB3 nuclear pore complex interacting protein family, member B3
P3H2 prolyl 3-hydroxylase 2
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PDE8B phosphodiesterase 8B
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PXDN peroxidasin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SCD5 stearoyl-CoA desaturase 5
SELE selectin E
SNX7 sorting nexin 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAB1 stabilin 1
SULF1 sulfatase 1
SYNM synemin, intermediate filament protein
TF transferrin
TM9SF3 transmembrane 9 superfamily member 3
TRIM29 tripartite motif containing 29
TSPAN12 tetraspanin 12
TUSC3 tumor suppressor candidate 3
UBE2J1 ubiquitin-conjugating enzyme E2, J1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZHX2 zinc fingers and homeoboxes 2
ZNF264 zinc finger protein 264