BRD-K63630713_ethacrynic acid_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K63630713_ethacrynic acid_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADIPOQ adiponectin, C1Q and collagen domain containing
AGR2 anterior gradient 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
CBR1 carbonyl reductase 1
COMP cartilage oligomeric matrix protein
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
DUSP3 dual specificity phosphatase 3
DUSP6 dual specificity phosphatase 6
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FABP4 fatty acid binding protein 4, adipocyte
FAM134C family with sequence similarity 134, member C
FNDC3B fibronectin type III domain containing 3B
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GLS glutaminase
GPER1 G protein-coupled estrogen receptor 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRN granulin
GUSBP3 glucuronidase, beta pseudogene 3
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
INTS6 integrator complex subunit 6
KYNU kynureninase
LRP10 low density lipoprotein receptor-related protein 10
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NRN1 neuritin 1
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
PPARG peroxisome proliferator-activated receptor gamma
REXO2 RNA exonuclease 2
RGS4 regulator of G-protein signaling 4
RIT1 Ras-like without CAAX 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STK38 serine/threonine kinase 38
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNPO1 transportin 1
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BRCA1 breast cancer 1, early onset
CCND2 cyclin D2
CCNE2 cyclin E2
CD200 CD200 molecule
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CENPU centromere protein U
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM60A family with sequence similarity 60, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FJX1 four jointed box 1 (Drosophila)
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GNAS GNAS complex locus
HELLS helicase, lymphoid-specific
INPP5F inositol polyphosphate-5-phosphatase F
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
LOC100505650 uncharacterized LOC100505650
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MSH2 mutS homolog 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPTX2 neuronal pentraxin II
ORC6 origin recognition complex, subunit 6
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAI14 retinoic acid induced 14
RANBP1 RAN binding protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SDF2L1 stromal cell-derived factor 2-like 1
SVIL supervillin
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UQCRC2 ubiquinol-cytochrome c reductase core protein II
VIM vimentin
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein