BRD-K63606607_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

205 genes differentially expressed following the BRD-K63606607_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C3 aldo-keto reductase family 1, member C3
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BRD4 bromodomain containing 4
CAPZB capping protein (actin filament) muscle Z-line, beta
CCL20 chemokine (C-C motif) ligand 20
CDCA4 cell division cycle associated 4
CPM carboxypeptidase M
CTSB cathepsin B
CTSC cathepsin C
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
ELF1 E74-like factor 1 (ets domain transcription factor)
FAM46A family with sequence similarity 46, member A
FAM60A family with sequence similarity 60, member A
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
GADD45B growth arrest and DNA-damage-inducible, beta
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KDM6B lysine (K)-specific demethylase 6B
KLF6 Kruppel-like factor 6
KLK11 kallikrein-related peptidase 11
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDLR low density lipoprotein receptor
LEPROT leptin receptor overlapping transcript
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPL1 nucleoporin like 1
NXN nucleoredoxin
PKN2 protein kinase N2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRO protein tyrosine phosphatase, receptor type, O
RBM15 RNA binding motif protein 15
RBMS1 RNA binding motif, single stranded interacting protein 1
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SIK3 SIK family kinase 3
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STOM stomatin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM4 tropomyosin 4
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UBR4 ubiquitin protein ligase E3 component n-recognin 4
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AIM1 absent in melanoma 1
ALAS1 5'-aminolevulinate synthase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATMIN ATM interactor
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR3 carbonyl reductase 3
CBR4 carbonyl reductase 4
CCND2 cyclin D2
CDK4 cyclin-dependent kinase 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CECR1 cat eye syndrome chromosome region, candidate 1
CPE carboxypeptidase E
CSK c-src tyrosine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
FANCF Fanconi anemia, complementation group F
FGL2 fibrinogen-like 2
FRZB frizzled-related protein
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJA1 gap junction protein, alpha 1, 43kDa
GUSBP11 glucuronidase, beta pseudogene 11
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INTS3 integrator complex subunit 3
JCHAIN joining chain of multimeric IgA and IgM
LDAH lipid droplet associated hydrolase
LRRC8D leucine rich repeat containing 8 family, member D
MAT2A methionine adenosyltransferase II, alpha
NMRK1 nicotinamide riboside kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NREP neuronal regeneration related protein
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDGFA platelet-derived growth factor alpha polypeptide
PIP prolactin-induced protein
PLK2 polo-like kinase 2
PNN pinin, desmosome associated protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
RAP2A RAP2A, member of RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNASE6 ribonuclease, RNase A family, k6
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SEPT9 septin 9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
STEAP3 STEAP family member 3, metalloreductase
TBC1D31 TBC1 domain family, member 31
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TPBG trophoblast glycoprotein
TRIM14 tripartite motif containing 14
TRIP6 thyroid hormone receptor interactor 6
TSPAN8 tetraspanin 8
USP34 ubiquitin specific peptidase 34
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZC3H14 zinc finger CCCH-type containing 14
ZNF185 zinc finger protein 185 (LIM domain)
ZNF302 zinc finger protein 302