BRD-K63606607_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

226 genes differentially expressed following the BRD-K63606607_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
AKAP9 A kinase (PRKA) anchor protein 9
ARHGAP29 Rho GTPase activating protein 29
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG2 BTG family, member 2
CALR calreticulin
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT2 CCR4-NOT transcription complex, subunit 2
COL11A1 collagen, type XI, alpha 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DPT dermatopontin
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF4A1 eukaryotic translation initiation factor 4A1
FAM60A family with sequence similarity 60, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA4 golgin A4
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
NACA nascent polypeptide-associated complex alpha subunit
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
OPHN1 oligophrenin 1
OXSR1 oxidative stress responsive 1
PCBP2 poly(rC) binding protein 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PELI2 pellino E3 ubiquitin protein ligase family member 2
PENK proenkephalin
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RABGGTB Rab geranylgeranyltransferase, beta subunit
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RLF rearranged L-myc fusion
RPL10 ribosomal protein L10
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPAG9 sperm associated antigen 9
SRRM2 serine/arginine repetitive matrix 2
SRSF10 serine/arginine-rich splicing factor 10
SRSF7 serine/arginine-rich splicing factor 7
STOM stomatin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFRC transferrin receptor
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM123 transmembrane protein 123
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D2 TSC22 domain family, member 2
TXNL4B thioredoxin-like 4B
WSB1 WD repeat and SOCS box containing 1
YARS tyrosyl-tRNA synthetase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBED2 zinc finger, BED-type containing 2
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZMYM2 zinc finger, MYM-type 2
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANKRD10 ankyrin repeat domain 10
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
ASF1A anti-silencing function 1A histone chaperone
ATMIN ATM interactor
C2ORF68 chromosome 2 open reading frame 68
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CADPS2 Ca++-dependent secretion activator 2
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAXX death-domain associated protein
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
FAM208A family with sequence similarity 208, member A
FANCF Fanconi anemia, complementation group F
FBXW2 F-box and WD repeat domain containing 2
GAS1 growth arrest-specific 1
GAS2 growth arrest-specific 2
GIMAP6 GTPase, IMAP family member 6
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX2 glutathione peroxidase 2
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXA5 homeobox A5
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDO1 indoleamine 2,3-dioxygenase 1
IFNGR1 interferon gamma receptor 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIF1A kinesin family member 1A
KRT17 keratin 17, type I
LCMT2 leucine carboxyl methyltransferase 2
LDAH lipid droplet associated hydrolase
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
METTL13 methyltransferase like 13
MFSD12 major facilitator superfamily domain containing 12
MSH6 mutS homolog 6
MSLN mesothelin
MUC4 mucin 4, cell surface associated
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDRG2 NDRG family member 2
NMRK1 nicotinamide riboside kinase 1
NNMT nicotinamide N-methyltransferase
NRCAM neuronal cell adhesion molecule
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUP62 nucleoporin 62kDa
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QPCT glutaminyl-peptide cyclotransferase
RAP2A RAP2A, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SEPT10 septin 10
SKAP2 src kinase associated phosphoprotein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A46 solute carrier family 25, member 46
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SPRR3 small proline-rich protein 3
SPTSSA serine palmitoyltransferase, small subunit A
STARD7 StAR-related lipid transfer (START) domain containing 7
TBC1D4 TBC1 domain family, member 4
THAP11 THAP domain containing 11
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TRIM29 tripartite motif containing 29
TUBB tubulin, beta class I
TUBGCP3 tubulin, gamma complex associated protein 3
TXNDC9 thioredoxin domain containing 9
VCAN versican
VGLL4 vestigial-like family member 4
WNT5A wingless-type MMTV integration site family, member 5A