BRD-K63550407_Erythromycin_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K63550407_Erythromycin_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
APP amyloid beta (A4) precursor protein
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C10ORF10 chromosome 10 open reading frame 10
CALR calreticulin
CASP1 caspase 1, apoptosis-related cysteine peptidase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL6A2 collagen, type VI, alpha 2
CTNND1 catenin (cadherin-associated protein), delta 1
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
GAL galanin/GMAP prepropeptide
GAS6 growth arrest-specific 6
IGHM immunoglobulin heavy constant mu
KLK5 kallikrein-related peptidase 5
LGALS1 lectin, galactoside-binding, soluble, 1
MAOA monoamine oxidase A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
NT5E 5'-nucleotidase, ecto (CD73)
PLAU plasminogen activator, urokinase
PON3 paraoxonase 3
PRUNE2 prune homolog 2 (Drosophila)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SFRP1 secreted frizzled-related protein 1
SOX9 SRY (sex determining region Y)-box 9
SPON2 spondin 2, extracellular matrix protein
SRGN serglycin
TDO2 tryptophan 2,3-dioxygenase
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP13A3 ATPase type 13A3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CDK4 cyclin-dependent kinase 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHPT1 choline phosphotransferase 1
CLIC5 chloride intracellular channel 5
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CRYAB crystallin, alpha B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EBAG9 estrogen receptor binding site associated, antigen, 9
EBNA1BP2 EBNA1 binding protein 2
EBP emopamil binding protein (sterol isomerase)
EED embryonic ectoderm development
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENOPH1 enolase-phosphatase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLTF helicase-like transcription factor
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPB8 heat shock 22kDa protein 8
KDM5D lysine (K)-specific demethylase 5D
KIF2C kinesin family member 2C
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYPLA1 lysophospholipase I
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MET MET proto-oncogene, receptor tyrosine kinase
METTL5 methyltransferase like 5
MOAP1 modulator of apoptosis 1
MPZL1 myelin protein zero-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NKX3-1 NK3 homeobox 1
NNT nicotinamide nucleotide transhydrogenase
NPC1 Niemann-Pick disease, type C1
NRCAM neuronal cell adhesion molecule
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PCYOX1 prenylcysteine oxidase 1
PEG10 paternally expressed 10
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PUS7 pseudouridylate synthase 7 (putative)
RAB40B RAB40B, member RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOBTB3 Rho-related BTB domain containing 3
RPS27L ribosomal protein S27-like
RRP1B ribosomal RNA processing 1B
SF1 splicing factor 1
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMS spermine synthase
SORBS1 sorbin and SH3 domain containing 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STOM stomatin
SYBU syntabulin (syntaxin-interacting)
TBC1D16 TBC1 domain family, member 16
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TM4SF1 transmembrane 4 L six family member 1
TMEM165 transmembrane protein 165
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNNC1 troponin C type 1 (slow)
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAK2 trafficking protein, kinesin binding 2
TSNAX translin-associated factor X
TSPAN13 tetraspanin 13
TSPYL1 TSPY-like 1
TYMS thymidylate synthetase
UBQLN2 ubiquilin 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP1 ubiquitin specific peptidase 1
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131