BRD-K63068307_ZSTK-474_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

207 genes differentially expressed following the BRD-K63068307_ZSTK-474_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AGR2 anterior gradient 2
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BCAS3 breast carcinoma amplified sequence 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CYTH1 cytohesin 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOC1 exocyst complex component 1
FOXO3 forkhead box O3
FRMD4B FERM domain containing 4B
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
GALC galactosylceramidase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLUL glutamate-ammonia ligase
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGBP1 immunoglobulin (CD79A) binding protein 1
KAT6B K(lysine) acetyltransferase 6B
KIAA0355 KIAA0355
KLHDC2 kelch domain containing 2
KRT19 keratin 19, type I
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
MLPH melanophilin
MOAP1 modulator of apoptosis 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYLIP myosin regulatory light chain interacting protein
NBR1 neighbor of BRCA1 gene 1
NELL2 NEL-like 2 (chicken)
NPIPB3 nuclear pore complex interacting protein family, member B3
PLAGL1 pleiomorphic adenoma gene-like 1
PLTP phospholipid transfer protein
PLXNB2 plexin B2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
QARS glutaminyl-tRNA synthetase
QPRT quinolinate phosphoribosyltransferase
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS10 regulator of G-protein signaling 10
RPL36 ribosomal protein L36
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SECISBP2L SECIS binding protein 2-like
SELENBP1 selenium binding protein 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC25A46 solute carrier family 25, member 46
SLC38A2 solute carrier family 38, member 2
SLC44A4 solute carrier family 44, member 4
SNAP23 synaptosomal-associated protein, 23kDa
SPDEF SAM pointed domain containing ETS transcription factor
SPG11 spastic paraplegia 11 (autosomal recessive)
SRGN serglycin
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMC5 transmembrane channel-like 5
TMEM63A transmembrane protein 63A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
VEGFA vascular endothelial growth factor A
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AFP alpha-fetoprotein
AHSG alpha-2-HS-glycoprotein
ALB albumin
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CTPS1 CTP synthase 1
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DSP desmoplakin
EBP emopamil binding protein (sterol isomerase)
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GPC3 glypican 3
GRB14 growth factor receptor-bound protein 14
GZMK granzyme K (granzyme 3; tryptase II)
H2AFX H2A histone family, member X
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LBR lamin B receptor
LMO4 LIM domain only 4
LTB lymphotoxin beta (TNF superfamily, member 3)
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE8B phosphodiesterase 8B
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
SDC2 syndecan 2
SDF2L1 stromal cell-derived factor 2-like 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPRR1B small proline-rich protein 1B
SRM spermidine synthase
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZMIZ1 zinc finger, MIZ-type containing 1
ZWINT ZW10 interacting kinetochore protein