BRD-K63068307_ZSTK-474_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

199 genes differentially expressed following the BRD-K63068307_ZSTK-474_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AREG amphiregulin
ATP9A ATPase, class II, type 9A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTF3 basic transcription factor 3
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CD302 CD302 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CNN1 calponin 1, basic, smooth muscle
COL4A1 collagen, type IV, alpha 1
COL8A2 collagen, type VIII, alpha 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSK cathepsin K
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EMP1 epithelial membrane protein 1
ETHE1 ethylmalonic encephalopathy 1
F2R coagulation factor II (thrombin) receptor
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXF1 forkhead box F1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAA glucosidase, alpha; acid
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HMGA2 high mobility group AT-hook 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
JAG1 jagged 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5B lysine (K)-specific demethylase 5B
KIZ kizuna centrosomal protein
LAMA4 laminin, alpha 4
LAMC2 laminin, gamma 2
LEPR leptin receptor
LEPROT leptin receptor overlapping transcript
LITAF lipopolysaccharide-induced TNF factor
LMOD1 leiomodin 1 (smooth muscle)
LTA4H leukotriene A4 hydrolase
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2B1 mannosidase, alpha, class 2B, member 1
N4BP2L1 NEDD4 binding protein 2-like 1
NAP1L1 nucleosome assembly protein 1-like 1
NBR1 neighbor of BRCA1 gene 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NID1 nidogen 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
QARS glutaminyl-tRNA synthetase
RAB13 RAB13, member RAS oncogene family
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC1 serine incorporator 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLK STE20-like kinase
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
SSPN sarcospan
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
STON1 stonin 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGM2 transglutaminase 2
TIMP2 TIMP metallopeptidase inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTA1 actin, alpha 1, skeletal muscle
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AURKA aurora kinase A
BHLHE40 basic helix-loop-helix family, member e40
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CALB2 calbindin 2
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EBP emopamil binding protein (sterol isomerase)
ENO1 enolase 1, (alpha)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FOXM1 forkhead box M1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA14 heat shock 70kDa protein 14
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
LMO4 LIM domain only 4
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSMO1 methylsterol monooxygenase 1
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NEB nebulin
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NPY1R neuropeptide Y receptor Y1
PARP2 poly (ADP-ribose) polymerase 2
PCCB propionyl CoA carboxylase, beta polypeptide
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PSAT1 phosphoserine aminotransferase 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAD23B RAD23 homolog B (S. cerevisiae)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SDF2L1 stromal cell-derived factor 2-like 1
SEPHS1 selenophosphate synthetase 1
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TNNT1 troponin T type 1 (skeletal, slow)
TPX2 TPX2, microtubule-associated
TTN titin
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein