BRD-K63068307_ZSTK-474_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-K63068307_ZSTK-474_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
AQP3 aquaporin 3 (Gill blood group)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCAM basal cell adhesion molecule (Lutheran blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCL21 chemokine (C-C motif) ligand 21
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CREBL2 cAMP responsive element binding protein-like 2
CRIP1 cysteine-rich protein 1 (intestinal)
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOCK1 dedicator of cytokinesis 1
DSP desmoplakin
DST dystonin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FAM63A family with sequence similarity 63, member A
FMO5 flavin containing monooxygenase 5
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GRAMD1C GRAM domain containing 1C
GSTZ1 glutathione S-transferase zeta 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IL6R interleukin 6 receptor
INSR insulin receptor
JMJD1C jumonji domain containing 1C
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LMBRD1 LMBR1 domain containing 1
LRP10 low density lipoprotein receptor-related protein 10
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP7 microtubule-associated protein 7
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MKRN1 makorin ring finger protein 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MVP major vault protein
MYLIP myosin regulatory light chain interacting protein
MYO1D myosin ID
MYO6 myosin VI
NBR1 neighbor of BRCA1 gene 1
NCOA2 nuclear receptor coactivator 2
ORAI3 ORAI calcium release-activated calcium modulator 3
OXTR oxytocin receptor
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PGRMC2 progesterone receptor membrane component 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLSCR4 phospholipid scramblase 4
PRSS8 protease, serine, 8
RAB31 RAB31, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RB1CC1 RB1-inducible coiled-coil 1
RBM47 RNA binding motif protein 47
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SERINC1 serine incorporator 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SWAP70 SWAP switching B-cell complex 70kDa subunit
TACC1 transforming, acidic coiled-coil containing protein 1
TCF4 transcription factor 4
TGFBR3 transforming growth factor, beta receptor III
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM50A transmembrane protein 50A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TSC22D3 TSC22 domain family, member 3
ULK1 unc-51 like autophagy activating kinase 1
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CCK cholecystokinin
CCNB1 cyclin B1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CENPU centromere protein U
CKAP4 cytoskeleton-associated protein 4
CNN1 calponin 1, basic, smooth muscle
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EXOSC8 exosome component 8
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HELLS helicase, lymphoid-specific
IARS isoleucyl-tRNA synthetase
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IL1RN interleukin 1 receptor antagonist
LIPG lipase, endothelial
LMNB1 lamin B1
LPL lipoprotein lipase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAK16 MAK16 homolog (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MINA MYC induced nuclear antigen
MMP7 matrix metallopeptidase 7
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH11 myosin, heavy chain 11, smooth muscle
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRIP1 nuclear receptor interacting protein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFKP phosphofructokinase, platelet
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
PLN phospholamban
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTRF polymerase I and transcript release factor
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC43A3 solute carrier family 43, member 3
SRM spermidine synthase
TFRC transferrin receptor
TMEM109 transmembrane protein 109
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein