BRD-K63068307_ZSTK-474_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K63068307_ZSTK-474_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
AQP9 aquaporin 9
ASRGL1 asparaginase like 1
C10ORF10 chromosome 10 open reading frame 10
C3AR1 complement component 3a receptor 1
CD14 CD14 molecule
CD163 CD163 molecule
CFD complement factor D (adipsin)
CHN1 chimerin 1
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DEFB1 defensin, beta 1
DMXL2 Dmx-like 2
DPYD dihydropyrimidine dehydrogenase
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
GATA2 GATA binding protein 2
GIMAP4 GTPase, IMAP family member 4
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
ICAM2 intercellular adhesion molecule 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCTP1 multiple C2 domains, transmembrane 1
MMRN1 multimerin 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTSS1 metastasis suppressor 1
NID1 nidogen 1
NNMT nicotinamide N-methyltransferase
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFTPA2 surfactant protein A2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFEC transcription factor EC
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM100 transmembrane protein 100
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22
VCAN versican
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
C2CD2 C2 calcium-dependent domain containing 2
CD44 CD44 molecule (Indian blood group)
COL15A1 collagen, type XV, alpha 1
CRISP3 cysteine-rich secretory protein 3
ELN elastin
FKBP4 FK506 binding protein 4, 59kDa
G0S2 G0/G1 switch 2
GCLC glutamate-cysteine ligase, catalytic subunit
GOLGA4 golgin A4
IL6ST interleukin 6 signal transducer
KIAA0485 uncharacterized LOC57235
NQO1 NAD(P)H dehydrogenase, quinone 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLAU plasminogen activator, urokinase
RPA3 replication protein A3, 14kDa
SATB1 SATB homeobox 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERINC5 serine incorporator 5
STC1 stanniocalcin 1
STC2 stanniocalcin 2
THBS4 thrombospondin 4
TUBA4A tubulin, alpha 4a