BRD-K63068307_ZSTK-474_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K63068307_ZSTK-474_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
ANKRD10 ankyrin repeat domain 10
BEX4 brain expressed, X-linked 4
BTBD3 BTB (POZ) domain containing 3
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCDC92 coiled-coil domain containing 92
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
DAPK1 death-associated protein kinase 1
DES desmin
EPHA3 EPH receptor A3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN1 fibrillin 1
GAS6 growth arrest-specific 6
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HDAC9 histone deacetylase 9
HEBP1 heme binding protein 1
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-E major histocompatibility complex, class I, E
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
INHBA inhibin, beta A
IPO7 importin 7
IRS2 insulin receptor substrate 2
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC283683 uncharacterized LOC283683
LYZ lysozyme
MANSC1 MANSC domain containing 1
MFAP5 microfibrillar associated protein 5
MPDZ multiple PDZ domain protein
MVP major vault protein
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
PERP PERP, TP53 apoptosis effector
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLXNC1 plexin C1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RPL22 ribosomal protein L22
SATB1 SATB homeobox 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOD2 superoxide dismutase 2, mitochondrial
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SVIL supervillin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TGFBI transforming growth factor, beta-induced, 68kDa
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ALOX15B arachidonate 15-lipoxygenase, type B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AURKA aurora kinase A
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBP emopamil binding protein (sterol isomerase)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPC3 glypican 3
GPI glucose-6-phosphate isomerase
HAT1 histone acetyltransferase 1
HSPA14 heat shock 70kDa protein 14
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
LUM lumican
MALL mal, T-cell differentiation protein-like
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MREG melanoregulin
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUSAP1 nucleolar and spindle associated protein 1
PCP4 Purkinje cell protein 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX1 peroxiredoxin 1
PRR15L proline rich 15-like
PTN pleiotrophin
RAI14 retinoic acid induced 14
RFC4 replication factor C (activator 1) 4, 37kDa
RGS2 regulator of G-protein signaling 2
RIT1 Ras-like without CAAX 1
RRM2 ribonucleotide reductase M2
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SHCBP1 SHC SH2-domain binding protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SPC25 SPC25, NDC80 kinetochore complex component
SUSD4 sushi domain containing 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TF transferrin
TOR3A torsin family 3, member A
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1