BRD-K62970326_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K62970326_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
CAPN2 calpain 2, (m/II) large subunit
CBS cystathionine-beta-synthase
CERS6 ceramide synthase 6
CHN1 chimerin 1
CLC Charcot-Leyden crystal galectin
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6A glycoprotein M6A
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
JUN jun proto-oncogene
KRT17 keratin 17, type I
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NBPF10 neuroblastoma breakpoint family, member 10
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PDIA3 protein disulfide isomerase family A, member 3
PLXNB2 plexin B2
PTN pleiotrophin
RAP1GAP RAP1 GTPase activating protein
S100A8 S100 calcium binding protein A8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TPM1 tropomyosin 1 (alpha)

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANO1 anoctamin 1, calcium activated chloride channel
ATF1 activating transcription factor 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CDK1 cyclin-dependent kinase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COPS7A COP9 signalosome subunit 7A
CXCL12 chemokine (C-X-C motif) ligand 12
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERH enhancer of rudimentary homolog (Drosophila)
ESR1 estrogen receptor 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSAP gamma-secretase activating protein
HADH hydroxyacyl-CoA dehydrogenase
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0101 KIAA0101
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MBP myelin basic protein
MED21 mediator complex subunit 21
MELK maternal embryonic leucine zipper kinase
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
PCNA proliferating cell nuclear antigen
PNP purine nucleoside phosphorylase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRDX3 peroxiredoxin 3
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASE4 ribonuclease, RNase A family, 4
TFPI2 tissue factor pathway inhibitor 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
WWTR1 WW domain containing transcription regulator 1