BRD-K62965247_Tipifarnib-P2_THP1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

102 genes differentially expressed following the BRD-K62965247_Tipifarnib-P2_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
ALDOB aldolase B, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
CD52 CD52 molecule
CES2 carboxylesterase 2
CFD complement factor D (adipsin)
CLU clusterin
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DST dystonin
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDN3 endothelin 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
GNAS GNAS complex locus
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0226L KIAA0226-like
MBOAT7 membrane bound O-acyltransferase domain containing 7
MYH11 myosin, heavy chain 11, smooth muscle
NARFL nuclear prelamin A recognition factor-like
NT5E 5'-nucleotidase, ecto (CD73)
PDGFA platelet-derived growth factor alpha polypeptide
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTPRO protein tyrosine phosphatase, receptor type, O
PXDN peroxidasin
REG1A regenerating islet-derived 1 alpha
SCGB1D2 secretoglobin, family 1D, member 2
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A1 solute carrier family 38, member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SYNM synemin, intermediate filament protein
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN5 tetraspanin 5
TUBB2A tubulin, beta 2A class IIa
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKAP11 A kinase (PRKA) anchor protein 11
BST2 bone marrow stromal cell antigen 2
C5ORF30 chromosome 5 open reading frame 30
CCDC86 coiled-coil domain containing 86
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYCS cytochrome c, somatic
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ELAVL1 ELAV like RNA binding protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
IGL immunoglobulin lambda locus
IVNS1ABP influenza virus NS1A binding protein
KLK11 kallikrein-related peptidase 11
LUM lumican
M6PR mannose-6-phosphate receptor (cation dependent)
MARCKSL1 MARCKS-like 1
MLPH melanophilin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP16 NOP16 nucleolar protein
NQO1 NAD(P)H dehydrogenase, quinone 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PEG3 paternally expressed 3
PLAC8 placenta-specific 8
PPAT phosphoribosyl pyrophosphate amidotransferase
RNF167 ring finger protein 167
S100A12 S100 calcium binding protein A12
SDCCAG3 serologically defined colon cancer antigen 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMS spermine synthase
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIB2 tribbles pseudokinase 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8