BRD-K62818989_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K62818989_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARMCX2 armadillo repeat containing, X-linked 2
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
C1QA complement component 1, q subcomponent, A chain
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFLAR CASP8 and FADD-like apoptosis regulator
CNN3 calponin 3, acidic
CRABP2 cellular retinoic acid binding protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FMO2 flavin containing monooxygenase 2 (non-functional)
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HILPDA hypoxia inducible lipid droplet-associated
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPGDS hematopoietic prostaglandin D synthase
IER3 immediate early response 3
JCHAIN joining chain of multimeric IgA and IgM
LOC100505650 uncharacterized LOC100505650
LRRN3 leucine rich repeat neuronal 3
LTA4H leukotriene A4 hydrolase
LTBP2 latent transforming growth factor beta binding protein 2
LXN latexin
MLF1 myeloid leukemia factor 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLTP phospholipid transfer protein
PRAME preferentially expressed antigen in melanoma
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
RGS10 regulator of G-protein signaling 10
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFRP4 secreted frizzled-related protein 4
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SYNGR3 synaptogyrin 3
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
VAV3 vav 3 guanine nucleotide exchange factor
VSIG4 V-set and immunoglobulin domain containing 4
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
CA2 carbonic anhydrase II
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSA cathepsin A
CXCL9 chemokine (C-X-C motif) ligand 9
ELF1 E74-like factor 1 (ets domain transcription factor)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMG20B high mobility group 20B
LGALS3 lectin, galactoside-binding, soluble, 3
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAGEA3 melanoma antigen family A3
MFSD12 major facilitator superfamily domain containing 12
OLFM1 olfactomedin 1
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PPIF peptidylprolyl isomerase F
RBKS ribokinase
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC16A6 solute carrier family 16, member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SYNJ2 synaptojanin 2
TATDN2 TatD DNase domain containing 2