BRD-K62459624_T5212475_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

205 genes differentially expressed following the BRD-K62459624_T5212475_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
AGR2 anterior gradient 2
APOD apolipoprotein D
AREG amphiregulin
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CCNG2 cyclin G2
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSA cathepsin A
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFA5 defensin, alpha 5, Paneth cell-specific
DSP desmoplakin
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3L eukaryotic translation initiation factor 3, subunit L
EPCAM epithelial cell adhesion molecule
ERBB3 erb-b2 receptor tyrosine kinase 3
FN1 fibronectin 1
FNBP1 formin binding protein 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAA glucosidase, alpha; acid
GATA3 GATA binding protein 3
GCC2 GRIP and coiled-coil domain containing 2
GOLGA8A golgin A8 family, member A
GREB1 growth regulation by estrogen in breast cancer 1
GREM1 gremlin 1, DAN family BMP antagonist
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GRN granulin
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JUP junction plakoglobin
KRT18 keratin 18, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LRP10 low density lipoprotein receptor-related protein 10
MCOLN1 mucolipin 1
MFSD10 major facilitator superfamily domain containing 10
MVP major vault protein
MYOF myoferlin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OPN3 opsin 3
PERP PERP, TP53 apoptosis effector
PLCB4 phospholipase C, beta 4
PLEK2 pleckstrin 2
PLIN2 perilipin 2
PLXNA1 plexin A1
PLXNB2 plexin B2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTPRE protein tyrosine phosphatase, receptor type, E
RAB21 RAB21, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SESN1 sestrin 1
SH3YL1 SH3 and SYLF domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRGN serglycin
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SULF1 sulfatase 1
SVIL supervillin
TFF1 trefoil factor 1
TOB1 transducer of ERBB2, 1
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIM36 tripartite motif containing 36
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR13 WD repeat domain 13
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
C1QBP complement component 1, q subcomponent binding protein
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNI cyclin I
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLIC4 chloride intracellular channel 4
CLU clusterin
CNN3 calponin 3, acidic
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSTA cystatin A (stefin A)
CTSH cathepsin H
DEFB1 defensin, beta 1
EED embryonic ectoderm development
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM13A family with sequence similarity 13, member A
FAM60A family with sequence similarity 60, member A
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FXYD2 FXYD domain containing ion transport regulator 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GSTP1 glutathione S-transferase pi 1
HDDC2 HD domain containing 2
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOPX HOP homeobox
HOXC10 homeobox C10
HSPA14 heat shock 70kDa protein 14
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
LYZ lysozyme
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MECOM MDS1 and EVI1 complex locus
MED21 mediator complex subunit 21
MELK maternal embryonic leucine zipper kinase
MPC2 mitochondrial pyruvate carrier 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDNF neuron-derived neurotrophic factor
NDRG2 NDRG family member 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPR3 natriuretic peptide receptor 3
NT5DC2 5'-nucleotidase domain containing 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PROSC proline synthetase co-transcribed homolog (bacterial)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHOBTB3 Rho-related BTB domain containing 3
RRM1 ribonucleotide reductase M1
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SET SET nuclear proto-oncogene
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
SUB1 SUB1 homolog (S. cerevisiae)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAGLN2 transgelin 2
TCF4 transcription factor 4
TMEM126B transmembrane protein 126B
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WFDC2 WAP four-disulfide core domain 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon