BRD-K62459624_T5212475_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

355 genes differentially expressed following the BRD-K62459624_T5212475_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAM9 ADAM metallopeptidase domain 9
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CA4 carbonic anhydrase IV
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CCL4 chemokine (C-C motif) ligand 4
CD163 CD163 molecule
CD69 CD69 molecule
CD93 CD93 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CERS6 ceramide synthase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CTGF connective tissue growth factor
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOK5 docking protein 5
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM107A family with sequence similarity 107, member A
FAM69A family with sequence similarity 69, member A
FBN2 fibrillin 2
FMOD fibromodulin
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRB7 growth factor receptor-bound protein 7
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HPGDS hematopoietic prostaglandin D synthase
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
KIAA1462 KIAA1462
KIAA1598
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LTBP1 latent transforming growth factor beta binding protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MSLN mesothelin
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NPEPL1 aminopeptidase-like 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PCDH17 protocadherin 17
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZD2 PDZ domain containing 2
PLD3 phospholipase D family, member 3
PLK2 polo-like kinase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRO protein tyrosine phosphatase, receptor type, O
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAD Ras-related associated with diabetes
RSAD2 radical S-adenosyl methionine domain containing 2
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SUSD4 sushi domain containing 4
TCEAL2 transcription elongation factor A (SII)-like 2
TCF21 transcription factor 21
TEK TEK tyrosine kinase, endothelial
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
VAMP8 vesicle-associated membrane protein 8
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
WISP2 WNT1 inducible signaling pathway protein 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AMD1 adenosylmethionine decarboxylase 1
ARMCX6 armadillo repeat containing, X-linked 6
ATMIN ATM interactor
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CBX6 chromobox homolog 6
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDA cytidine deaminase
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNPY2 canopy FGF signaling regulator 2
COASY CoA synthase
COG2 component of oligomeric golgi complex 2
CORO1C coronin, actin binding protein, 1C
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST3 cystatin C
CTSH cathepsin H
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP4 dual specificity phosphatase 4
EIF4B eukaryotic translation initiation factor 4B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK1 ethanolamine kinase 1
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM111A family with sequence similarity 111, member A
FAM57A family with sequence similarity 57, member A
FBXO21 F-box protein 21
G0S2 G0/G1 switch 2
GOLT1B golgi transport 1B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLTF helicase-like transcription factor
HMG20B high mobility group 20B
HMGN3 high mobility group nucleosomal binding domain 3
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB7 homeobox B7
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IPO5 importin 5
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KLHL9 kelch-like family member 9
KRT10 keratin 10, type I
KRT7 keratin 7, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MPZL1 myelin protein zero-like 1
MTCL1 microtubule crosslinking factor 1
MTF2 metal response element binding transcription factor 2
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NNT nicotinamide nucleotide transhydrogenase
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PLIN3 perilipin 3
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
QPCT glutaminyl-peptide cyclotransferase
RAD23B RAD23 homolog B (S. cerevisiae)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RHOBTB3 Rho-related BTB domain containing 3
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
RPS4Y1 ribosomal protein S4, Y-linked 1
SAC3D1 SAC3 domain containing 1
SC5D sterol-C5-desaturase
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SF1 splicing factor 1
SFRP1 secreted frizzled-related protein 1
SGPL1 sphingosine-1-phosphate lyase 1
SLC25A46 solute carrier family 25, member 46
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D16 TBC1 domain family, member 16
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TRAM1 translocation associated membrane protein 1
TRAPPC4 trafficking protein particle complex 4
TSPAN13 tetraspanin 13
TWF1 twinfilin actin binding protein 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP22 ubiquitin specific peptidase 22
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VEZF1 vascular endothelial zinc finger 1
WWTR1 WW domain containing transcription regulator 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZCCHC24 zinc finger, CCHC domain containing 24