BRD-K62289640_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K62289640_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANKRD10 ankyrin repeat domain 10
BHLHE40 basic helix-loop-helix family, member e40
CCL5 chemokine (C-C motif) ligand 5
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CSTA cystatin A (stefin A)
CXCL11 chemokine (C-X-C motif) ligand 11
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FZD7 frizzled class receptor 7
GUSBP11 glucuronidase, beta pseudogene 11
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG1 insulin induced gene 1
IVNS1ABP influenza virus NS1A binding protein
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KRT23 keratin 23, type I
LGALS8 lectin, galactoside-binding, soluble, 8
MEST mesoderm specific transcript
MYO10 myosin X
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PNKP polynucleotide kinase 3'-phosphatase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC2 stanniocalcin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ATF5 activating transcription factor 5
B3GNT1
BAG3 BCL2-associated athanogene 3
CFD complement factor D (adipsin)
CLIC4 chloride intracellular channel 4
CPE carboxypeptidase E
CPT1A carnitine palmitoyltransferase 1A (liver)
CTBP1 C-terminal binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
EIF5A eukaryotic translation initiation factor 5A
ETFB electron-transfer-flavoprotein, beta polypeptide
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMG20B high mobility group 20B
HOXC6 homeobox C6
LTBP1 latent transforming growth factor beta binding protein 1
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
MME membrane metallo-endopeptidase
MREG melanoregulin
NME4 NME/NM23 nucleoside diphosphate kinase 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RASA4 RAS p21 protein activator 4
RPS27L ribosomal protein S27-like
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SET SET nuclear proto-oncogene
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
TSPYL5 TSPY-like 5