BRD-K62289640_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

210 genes differentially expressed following the BRD-K62289640_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP17A A kinase (PRKA) anchor protein 17A
ANKRD10 ankyrin repeat domain 10
ANKRD28 ankyrin repeat domain 28
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CCNA1 cyclin A1
CCNL1 cyclin L1
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLDND1 claudin domain containing 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CRY1 cryptochrome circadian clock 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
E2F2 E2F transcription factor 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FKBP11 FK506 binding protein 11, 19 kDa
FNBP4 formin binding protein 4
FNDC3A fibronectin type III domain containing 3A
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GPM6B glycoprotein M6B
H3F3B H3 histone, family 3B (H3.3B)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL13RA2 interleukin 13 receptor, alpha 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NBPF10 neuroblastoma breakpoint family, member 10
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
OPN3 opsin 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM7 small integral membrane protein 7
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRY2 sprouty homolog 2 (Drosophila)
SUCO SUN domain containing ossification factor
TAC1 tachykinin, precursor 1
TDO2 tryptophan 2,3-dioxygenase
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TRIM2 tripartite motif containing 2
TUBB2B tubulin, beta 2B class IIb
TWIST1 twist family bHLH transcription factor 1
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
ZBTB18 zinc finger and BTB domain containing 18
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZIC1 Zic family member 1
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACOT7 acyl-CoA thioesterase 7
ADI1 acireductone dioxygenase 1
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATF5 activating transcription factor 5
ATOX1 antioxidant 1 copper chaperone
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCND1 cyclin D1
CDK1 cyclin-dependent kinase 1
CETN2 centrin, EF-hand protein, 2
CLU clusterin
CSTA cystatin A (stefin A)
CTSC cathepsin C
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FLNA filamin A, alpha
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTF2H5 general transcription factor IIH, polypeptide 5
ICMT isoprenylcysteine carboxyl methyltransferase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KIAA0101 KIAA0101
LAGE3 L antigen family, member 3
LAP3 leucine aminopeptidase 3
LIG1 ligase I, DNA, ATP-dependent
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM3 minichromosome maintenance complex component 3
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NDN necdin, melanoma antigen (MAGE) family member
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPEPL1 aminopeptidase-like 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PITX1 paired-like homeodomain 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PTGDS prostaglandin D2 synthase 21kDa (brain)
QDPR quinoid dihydropteridine reductase
RAD51C RAD51 paralog C
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SEPP1 selenoprotein P, plasma, 1
SEPW1 selenoprotein W, 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TMEM106C transmembrane protein 106C
TMEM164 transmembrane protein 164
TRIP13 thyroid hormone receptor interactor 13
TSPAN4 tetraspanin 4
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TUSC2 tumor suppressor candidate 2
UNG uracil-DNA glycosylase
ZNF185 zinc finger protein 185 (LIM domain)
ZWINT ZW10 interacting kinetochore protein