BRD-K62221994_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K62221994_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADAM10 ADAM metallopeptidase domain 10
AGTR1 angiotensin II receptor, type 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CLCN3 chloride channel, voltage-sensitive 3
CLIC3 chloride intracellular channel 3
CPB1 carboxypeptidase B1 (tissue)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGR FGR proto-oncogene, Src family tyrosine kinase
HBB hemoglobin, beta
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IL15 interleukin 15
IL32 interleukin 32
KAZN kazrin, periplakin interacting protein
LDLR low density lipoprotein receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MSMO1 methylsterol monooxygenase 1
NEFH neurofilament, heavy polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PIP prolactin-induced protein
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RTN1 reticulon 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SQLE squalene epoxidase
TARP TCR gamma alternate reading frame protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TLR4 toll-like receptor 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIB3 tribbles pseudokinase 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VNN1 vanin 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASPN asporin
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
CD24 CD24 molecule
CD9 CD9 molecule
CTSB cathepsin B
EFNB2 ephrin-B2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
GMDS GDP-mannose 4,6-dehydratase
GNAS GNAS complex locus
GSN gelsolin
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HNRNPL heterogeneous nuclear ribonucleoprotein L
ITM2A integral membrane protein 2A
NFIB nuclear factor I/B
NUTF2 nuclear transport factor 2
PHACTR2 phosphatase and actin regulator 2
POSTN periostin, osteoblast specific factor
RCAN1 regulator of calcineurin 1
S100A10 S100 calcium binding protein A10
SEPP1 selenoprotein P, plasma, 1
TIMP3 TIMP metallopeptidase inhibitor 3
TOX thymocyte selection-associated high mobility group box