BRD-K62012036_GR-108_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K62012036_GR-108_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA5 annexin A5
BIRC5 baculoviral IAP repeat containing 5
CALU calumenin
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25B cell division cycle 25B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COMP cartilage oligomeric matrix protein
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
DDIT4 DNA-damage-inducible transcript 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ELL2 elongation factor, RNA polymerase II, 2
F3 coagulation factor III (thromboplastin, tissue factor)
FKBP1B FK506 binding protein 1B, 12.6 kDa
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
HES1 hes family bHLH transcription factor 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
IL7R interleukin 7 receptor
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF14 kinesin family member 14
KIF5B kinesin family member 5B
KRAS Kirsten rat sarcoma viral oncogene homolog
LDLR low density lipoprotein receptor
LPXN leupaxin
MALL mal, T-cell differentiation protein-like
MIR22HG MIR22 host gene
MMD monocyte to macrophage differentiation-associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEK2 NIMA-related kinase 2
NPY neuropeptide Y
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
RAB1A RAB1A, member RAS oncogene family
RPL37A ribosomal protein L37a
RTN4 reticulon 4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP3 TIMP metallopeptidase inhibitor 3
TRAM1 translocation associated membrane protein 1
TSPAN13 tetraspanin 13
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADGRL1 adhesion G protein-coupled receptor L1
CCDC85B coiled-coil domain containing 85B
CD320 CD320 molecule
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CLU clusterin
COL3A1 collagen, type III, alpha 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GAS1 growth arrest-specific 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LIG1 ligase I, DNA, ATP-dependent
LRPPRC leucine-rich pentatricopeptide repeat containing
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
MRPS27 mitochondrial ribosomal protein S27
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NAP1L1 nucleosome assembly protein 1-like 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKM phosphofructokinase, muscle
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
TARBP1 TAR (HIV-1) RNA binding protein 1
TP53 tumor protein p53
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
UNG uracil-DNA glycosylase
VCAM1 vascular cell adhesion molecule 1
ZFP36L1 ZFP36 ring finger protein-like 1