BRD-K61829047_7b-cis_NCIH1836_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K61829047_7b-cis_NCIH1836_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
APOC1 apolipoprotein C-I
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BLNK B-cell linker
C1QB complement component 1, q subcomponent, B chain
CAV1 caveolin 1, caveolae protein, 22kDa
CD44 CD44 molecule (Indian blood group)
COMT catechol-O-methyltransferase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EMC3 ER membrane protein complex subunit 3
EPRS glutamyl-prolyl-tRNA synthetase
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
HACD1 3-hydroxyacyl-CoA dehydratase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JMJD6 jumonji domain containing 6
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYBPC1 myosin binding protein C, slow type
N4BP2L2 NEDD4 binding protein 2-like 2
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PADI2 peptidyl arginine deiminase, type II
PCCB propionyl CoA carboxylase, beta polypeptide
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PLK2 polo-like kinase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
REEP5 receptor accessory protein 5
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAP18 Sin3A-associated protein, 18kDa
SERINC5 serine incorporator 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOCS2 suppressor of cytokine signaling 2
SQSTM1 sequestosome 1
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
SVIL supervillin
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TXNRD1 thioredoxin reductase 1
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKIRIN1 akirin 1
ARF3 ADP-ribosylation factor 3
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
COL3A1 collagen, type III, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTTN cortactin
CXCL14 chemokine (C-X-C motif) ligand 14
CYB561 cytochrome b561
DHRS1 dehydrogenase/reductase (SDR family) member 1
DNALI1 dynein, axonemal, light intermediate chain 1
DPYSL3 dihydropyrimidinase-like 3
DSTN destrin (actin depolymerizing factor)
EFNB2 ephrin-B2
EID1 EP300 interacting inhibitor of differentiation 1
FABP4 fatty acid binding protein 4, adipocyte
FAM127A family with sequence similarity 127, member A
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
HOPX HOP homeobox
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KRT1 keratin 1, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYPLA1 lysophospholipase I
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCKSL1 MARCKS-like 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMD monocyte to macrophage differentiation-associated
NDN necdin, melanoma antigen (MAGE) family member
NDRG3 NDRG family member 3
NELL2 NEL-like 2 (chicken)
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PSD3 pleckstrin and Sec7 domain containing 3
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAP2A RAP2A, member of RAS oncogene family
RBP1 retinol binding protein 1, cellular
REC8 REC8 meiotic recombination protein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAND1 SCAN domain containing 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SST somatostatin
SUB1 SUB1 homolog (S. cerevisiae)
TMEM109 transmembrane protein 109
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPPP3 tubulin polymerization-promoting protein family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TXLNA taxilin alpha
VCAM1 vascular cell adhesion molecule 1
WFDC2 WAP four-disulfide core domain 2
ZCCHC24 zinc finger, CCHC domain containing 24