BRD-K61829047_7b-cis_MDST8_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K61829047_7b-cis_MDST8_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BLNK B-cell linker
BLVRB biliverdin reductase B
CA2 carbonic anhydrase II
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
CNPY3 canopy FGF signaling regulator 3
COL6A1 collagen, type VI, alpha 1
CXCL10 chemokine (C-X-C motif) ligand 10
DENND2D DENN/MADD domain containing 2D
DSP desmoplakin
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FTH1 ferritin, heavy polypeptide 1
FZD6 frizzled class receptor 6
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF1R insulin-like growth factor 1 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITM2C integral membrane protein 2C
JUP junction plakoglobin
KLHL24 kelch-like family member 24
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
MAST4 microtubule associated serine/threonine kinase family member 4
MEF2A myocyte enhancer factor 2A
MMP11 matrix metallopeptidase 11
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKP2 plakophilin 2
PLIN2 perilipin 2
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
RAB25 RAB25, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS16 regulator of G-protein signaling 16
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIK1 salt-inducible kinase 1
SPRED2 sprouty-related, EVH1 domain containing 2
SULF1 sulfatase 1
TRAPPC6A trafficking protein particle complex 6A
TRDV3 T cell receptor delta variable 3
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WISP2 WNT1 inducible signaling pathway protein 2
ZNF165 zinc finger protein 165
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
APOD apolipoprotein D
BIRC2 baculoviral IAP repeat containing 2
BRCA1 breast cancer 1, early onset
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
EREG epiregulin
FASTKD5 FAST kinase domains 5
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HMGA2 high mobility group AT-hook 2
HN1L hematological and neurological expressed 1-like
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
LIPG lipase, endothelial
LTF lactotransferrin
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MCAM melanoma cell adhesion molecule
MFAP5 microfibrillar associated protein 5
MRFAP1L1 Morf4 family associated protein 1-like 1
NOTCH2 notch 2
NPAS2 neuronal PAS domain protein 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXPE3 neurexophilin and PC-esterase domain family, member 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARP2 poly (ADP-ribose) polymerase 2
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SNX11 sorting nexin 11
SRPX sushi-repeat containing protein, X-linked
SRSF11 serine/arginine-rich splicing factor 11
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
USP1 ubiquitin specific peptidase 1
VAT1 vesicle amine transport 1
VCAN versican
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2