BRD-K61776140_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K61776140_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL3 acyl-CoA synthetase long-chain family member 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BTG2 BTG family, member 2
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERP44 endoplasmic reticulum protein 44
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3B fibronectin type III domain containing 3B
GARS glycyl-tRNA synthetase
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1A interleukin 1, alpha
INSIG1 insulin induced gene 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSAT1 phosphoserine aminotransferase 1
RGS5 regulator of G-protein signaling 5
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TARS threonyl-tRNA synthetase
TBX3 T-box 3
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UFM1 ubiquitin-fold modifier 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
FGFR3 fibroblast growth factor receptor 3
HES1 hes family bHLH transcription factor 1
KRT17 keratin 17, type I
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)