BRD-K61737877_VEGF Receptor 2 Kinase Inhibitor IV_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K61737877_VEGF Receptor 2 Kinase Inhibitor IV_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMACR alpha-methylacyl-CoA racemase
AQP3 aquaporin 3 (Gill blood group)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CA1 carbonic anhydrase I
CCND2 cyclin D2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CKB creatine kinase, brain
COMT catechol-O-methyltransferase
CXCL14 chemokine (C-X-C motif) ligand 14
CYC1 cytochrome c-1
DSC2 desmocollin 2
EDN3 endothelin 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GPM6B glycoprotein M6B
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRF8 interferon regulatory factor 8
KIF5C kinesin family member 5C
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT6A keratin 6A, type II
LAMP5 lysosomal-associated membrane protein family, member 5
METTL7A methyltransferase like 7A
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
P3H2 prolyl 3-hydroxylase 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLTP phospholipid transfer protein
POU4F1 POU class 4 homeobox 1
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRSS21 protease, serine, 21 (testisin)
S100A12 S100 calcium binding protein A12
SCRG1 stimulator of chondrogenesis 1
SFRP1 secreted frizzled-related protein 1
SFTPC surfactant protein C
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STAR steroidogenic acute regulatory protein
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
TMEM45A transmembrane protein 45A
TRIM2 tripartite motif containing 2
TSPAN1 tetraspanin 1
TSPAN7 tetraspanin 7
TSPYL5 TSPY-like 5
TUBB6 tubulin, beta 6 class V
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ANGPTL2 angiopoietin-like 2
ANPEP alanyl (membrane) aminopeptidase
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CHRDL1 chordin-like 1
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CYTH1 cytohesin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FBN1 fibrillin 1
GAS1 growth arrest-specific 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IER3 immediate early response 3
ITGAV integrin, alpha V
KRT19 keratin 19, type I
MMP2 matrix metallopeptidase 2
MXRA5 matrix-remodelling associated 5
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFML2B olfactomedin-like 2B
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPP1 selenoprotein P, plasma, 1
SEPT11 septin 11
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TUBB2A tubulin, beta 2A class IIa
TYRP1 tyrosinase-related protein 1
ZNF430 zinc finger protein 430
ZNF91 zinc finger protein 91