BRD-K61717269_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K61717269_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BLCAP bladder cancer associated protein
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA9 carbonic anhydrase IX
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR3 early growth response 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
F3 coagulation factor III (thromboplastin, tissue factor)
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FAM162A family with sequence similarity 162, member A
FAM57A family with sequence similarity 57, member A
FBXO2 F-box protein 2
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPI glucose-6-phosphate isomerase
GPX3 glutathione peroxidase 3
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
INSIG2 insulin induced gene 2
ITM2A integral membrane protein 2A
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LOX lysyl oxidase
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MEF2A myocyte enhancer factor 2A
MT1E metallothionein 1E
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLLP plasmolipin
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RNASET2 ribonuclease T2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TF transferrin
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TMEM100 transmembrane protein 100
TMEM45A transmembrane protein 45A
TNIP1 TNFAIP3 interacting protein 1
TNNC1 troponin C type 1 (slow)
TNS1 tensin 1
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
VEGFA vascular endothelial growth factor A
WDR45B WD repeat domain 45B

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AKT3 v-akt murine thymoma viral oncogene homolog 3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BCHE butyrylcholinesterase
CCL5 chemokine (C-C motif) ligand 5
CDC20 cell division cycle 20
CENPF centromere protein F, 350/400kDa
COL3A1 collagen, type III, alpha 1
ESR1 estrogen receptor 1
FAM69A family with sequence similarity 69, member A
FYB FYN binding protein
GATA3 GATA binding protein 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNLY granulysin
GTSE1 G-2 and S-phase expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
NRGN neurogranin (protein kinase C substrate, RC3)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLK1 polo-like kinase 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PSRC1 proline/serine-rich coiled-coil 1
RACGAP1 Rac GTPase activating protein 1
SCGB2A2 secretoglobin, family 2A, member 2
TDO2 tryptophan 2,3-dioxygenase
TGFBR3 transforming growth factor, beta receptor III
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPK1B uroplakin 1B