BRD-K61717269_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K61717269_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CKB creatine kinase, brain
CLIC4 chloride intracellular channel 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
EZR ezrin
FBN2 fibrillin 2
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GRK5 G protein-coupled receptor kinase 5
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HSPA13 heat shock protein 70kDa family, member 13
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IL1A interleukin 1, alpha
INHBA inhibin, beta A
INHBE inhibin, beta E
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
KRT6A keratin 6A, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRNP prion protein
PTHLH parathyroid hormone-like hormone
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SARS seryl-tRNA synthetase
SERTAD2 SERTA domain containing 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG4 sperm associated antigen 4
SPRED2 sprouty-related, EVH1 domain containing 2
STAR steroidogenic acute regulatory protein
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN5 tetraspanin 5
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ATF5 activating transcription factor 5
AURKA aurora kinase A
B3GNT1
BMP4 bone morphogenetic protein 4
CCNA2 cyclin A2
CCNF cyclin F
CDC25B cell division cycle 25B
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATA2 GATA binding protein 2
GTF3A general transcription factor IIIA
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
KIF20A kinesin family member 20A
MGLL monoglyceride lipase
MLEC malectin
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NUP62 nucleoporin 62kDa
PCDH9 protocadherin 9
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PON2 paraoxonase 2
REPIN1 replication initiator 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TXN thioredoxin
UBE2C ubiquitin-conjugating enzyme E2C