BRD-K61480498_GR-231_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-K61480498_GR-231_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
AOX1 aldehyde oxidase 1
ASS1 argininosuccinate synthase 1
AZU1 azurocidin 1
BIK BCL2-interacting killer (apoptosis-inducing)
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CAPN2 calpain 2, (m/II) large subunit
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CFH complement factor H
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP1 cysteine and glycine-rich protein 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
FKBP5 FK506 binding protein 5
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GSN gelsolin
HLA-E major histocompatibility complex, class I, E
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF9 Kruppel-like factor 9
KRT15 keratin 15, type I
LINC00341 long intergenic non-protein coding RNA 341
LPIN1 lipin 1
LTBP2 latent transforming growth factor beta binding protein 2
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSLN mesothelin
MT1X metallothionein 1X
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
OBSL1 obscurin-like 1
OPTN optineurin
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER1 period circadian clock 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKP2 plakophilin 2
PPL periplakin
PRTN3 proteinase 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
S100A10 S100 calcium binding protein A10
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC35F2 solute carrier family 35, member F2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SSPN sarcospan
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNPO synaptopodin
THBS3 thrombospondin 3
TMEM255A transmembrane protein 255A
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VNN1 vanin 1
WISP2 WNT1 inducible signaling pathway protein 2
ZBTB16 zinc finger and BTB domain containing 16
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTBD3 BTB (POZ) domain containing 3
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CD24 CD24 molecule
CD320 CD320 molecule
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CMC2 C-x(9)-C motif containing 2
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
EFHD2 EF-hand domain family, member D2
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCL Fanconi anemia, complementation group L
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HIST1H4C histone cluster 1, H4c
HMG20B high mobility group 20B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
LIG1 ligase I, DNA, ATP-dependent
LPAR1 lysophosphatidic acid receptor 1
LSM1 LSM1, U6 small nuclear RNA associated
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MFSD12 major facilitator superfamily domain containing 12
MREG melanoregulin
MRPL42 mitochondrial ribosomal protein L42
NCAPH non-SMC condensin I complex, subunit H
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NTS neurotensin
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OLFM1 olfactomedin 1
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PROSC proline synthetase co-transcribed homolog (bacterial)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRR7 proline rich 7 (synaptic)
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RAP1GAP RAP1 GTPase activating protein
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
RPL39L ribosomal protein L39-like
S100A1 S100 calcium binding protein A1
SDC2 syndecan 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT10 septin 10
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLIRP SRA stem-loop interacting RNA binding protein
SNRPG small nuclear ribonucleoprotein polypeptide G
SOWAHC sosondowah ankyrin repeat domain family member C
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
SRSF3 serine/arginine-rich splicing factor 3
SST somatostatin
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
TIMELESS timeless circadian clock
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
UBQLN2 ubiquilin 2
VRK1 vaccinia related kinase 1
WWTR1 WW domain containing transcription regulator 1
ZFP36L1 ZFP36 ring finger protein-like 1