BRD-K61401890_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K61401890_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL4A5 collagen, type IV, alpha 5
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
IGL immunoglobulin lambda locus
ISG20 interferon stimulated exonuclease gene 20kDa
KLF4 Kruppel-like factor 4 (gut)
LOC100505650 uncharacterized LOC100505650
PAWR PRKC, apoptosis, WT1, regulator
PHGDH phosphoglycerate dehydrogenase
PLK2 polo-like kinase 2
PRAF2 PRA1 domain family, member 2
PRUNE2 prune homolog 2 (Drosophila)
RAP1GAP RAP1 GTPase activating protein
RGS2 regulator of G-protein signaling 2
STC2 stanniocalcin 2
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADIRF adipogenesis regulatory factor
ASF1B anti-silencing function 1B histone chaperone
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
CCNA2 cyclin A2
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CKS1B CDC28 protein kinase regulatory subunit 1B
DHFR dihydrofolate reductase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUD1 glutamate dehydrogenase 1
HELLS helicase, lymphoid-specific
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1R1 interleukin 1 receptor, type I
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MELK maternal embryonic leucine zipper kinase
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SLBP stem-loop binding protein
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
TFPI2 tissue factor pathway inhibitor 2
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein