BRD-K61323504_SB 225002_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K61323504_SB 225002_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5A eukaryotic translation initiation factor 5A
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
NCAPG non-SMC condensin I complex, subunit G
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
PBK PDZ binding kinase
PDLIM5 PDZ and LIM domain 5
PTTG1 pituitary tumor-transforming 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STIL SCL/TAL1 interrupting locus
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
FABP7 fatty acid binding protein 7, brain
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
HOPX HOP homeobox
IGFBP5 insulin-like growth factor binding protein 5
MEF2C myocyte enhancer factor 2C
NEB nebulin
RGS5 regulator of G-protein signaling 5
SDC4 syndecan 4
SYNM synemin, intermediate filament protein
TCF4 transcription factor 4