BRD-K61323504_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K61323504_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRL1 adhesion G protein-coupled receptor L1
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CKB creatine kinase, brain
CLDN3 claudin 3
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DLK1 delta-like 1 homolog (Drosophila)
DSP desmoplakin
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
GATA3 GATA binding protein 3
GNAS GNAS complex locus
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INHBA inhibin, beta A
JUN jun proto-oncogene
KIAA0125 KIAA0125
KLHL21 kelch-like family member 21
KRT6B keratin 6B, type II
LOC100505650 uncharacterized LOC100505650
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1G metallothionein 1G
MYO1D myosin ID
MYO6 myosin VI
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PEG3 paternally expressed 3
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS10 regulator of G-protein signaling 10
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SYK spleen tyrosine kinase
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFRC transferrin receptor
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRPS1 trichorhinophalangeal syndrome I
TSPYL5 TSPY-like 5
VCAM1 vascular cell adhesion molecule 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BLVRB biliverdin reductase B
CAST calpastatin
CD36 CD36 molecule (thrombospondin receptor)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CSRP2 cysteine and glycine-rich protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
EGFR epidermal growth factor receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FRZB frizzled-related protein
GALC galactosylceramidase
HIST1H2BD histone cluster 1, H2bd
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IER3 immediate early response 3
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LEF1 lymphoid enhancer-binding factor 1
LYPLA1 lysophospholipase I
MEIS2 Meis homeobox 2
NID1 nidogen 1
NOSIP nitric oxide synthase interacting protein
NR2F1 nuclear receptor subfamily 2, group F, member 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SORBS1 sorbin and SH3 domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMC5 transmembrane channel-like 5
TMEM2 transmembrane protein 2
TNPO1 transportin 1
TUBB2A tubulin, beta 2A class IIa
UPP1 uridine phosphorylase 1
VCAN versican