BRD-K61250553_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K61250553_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
AK1 adenylate kinase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
CA2 carbonic anhydrase II
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLU clusterin
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DSG1 desmoglein 1
DUSP1 dual specificity phosphatase 1
FADS1 fatty acid desaturase 1
FAM63A family with sequence similarity 63, member A
FLG filaggrin
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GPX3 glutathione peroxidase 3
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
INSIG1 insulin induced gene 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIAA0125 KIAA0125
LDLR low density lipoprotein receptor
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
NEFH neurofilament, heavy polypeptide
NSDHL NAD(P) dependent steroid dehydrogenase-like
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3BP4 SH3-domain binding protein 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC43A3 solute carrier family 43, member 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS1 tensin 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FGG fibrinogen gamma chain
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1RAP interleukin 1 receptor accessory protein
KAT6B K(lysine) acetyltransferase 6B
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MAGEA3 melanoma antigen family A3
MGP matrix Gla protein
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
OLFM4 olfactomedin 4
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
RGS4 regulator of G-protein signaling 4
TFPI2 tissue factor pathway inhibitor 2
TUSC3 tumor suppressor candidate 3