BRD-K61105081_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K61105081_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARID5B AT rich interactive domain 5B (MRF1-like)
C3AR1 complement component 3a receptor 1
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CD200 CD200 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DCN decorin
DMXL2 Dmx-like 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DRAM1 DNA-damage regulated autophagy modulator 1
EAF2 ELL associated factor 2
EDNRB endothelin receptor type B
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM65B family with sequence similarity 65, member B
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KRT23 keratin 23, type I
LXN latexin
MARCKSL1 MARCKS-like 1
MCTP1 multiple C2 domains, transmembrane 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MSN moesin
NES nestin
NPTX2 neuronal pentraxin II
NTS neurotensin
OSBPL10 oxysterol binding protein-like 10
PBX1 pre-B-cell leukemia homeobox 1
PFKM phosphofructokinase, muscle
PLAT plasminogen activator, tissue
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGIS prostaglandin I2 (prostacyclin) synthase
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SALL2 spalt-like transcription factor 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNAI2 snail family zinc finger 2
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPBG trophoblast glycoprotein
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
VAV3 vav 3 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ASS1 argininosuccinate synthase 1
BLCAP bladder cancer associated protein
CES1 carboxylesterase 1
CLU clusterin
COL5A2 collagen, type V, alpha 2
DSP desmoplakin
F3 coagulation factor III (thromboplastin, tissue factor)
FLRT3 fibronectin leucine rich transmembrane protein 3
GRWD1 glutamate-rich WD repeat containing 1
H3F3B H3 histone, family 3B (H3.3B)
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
ITGB4 integrin, beta 4
KLF4 Kruppel-like factor 4 (gut)
LLGL2 lethal giant larvae homolog 2 (Drosophila)
MSLN mesothelin
NUP85 nucleoporin 85kDa
PDGFA platelet-derived growth factor alpha polypeptide
RNH1 ribonuclease/angiogenin inhibitor 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
TTN titin