BRD-K60870698_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K60870698_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AK4 adenylate kinase 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANKRD12 ankyrin repeat domain 12
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG3 BTG family, member 3
CES1 carboxylesterase 1
CHMP1B charged multivesicular body protein 1B
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DUSP3 dual specificity phosphatase 3
EAPP E2F-associated phosphoprotein
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPI glucose-6-phosphate isomerase
GPX2 glutathione peroxidase 2
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
LAPTM4B lysosomal protein transmembrane 4 beta
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MLF1 myeloid leukemia factor 1
MPO myeloperoxidase
MSLN mesothelin
MT1M metallothionein 1M
MT1X metallothionein 1X
NAMPT nicotinamide phosphoribosyltransferase
NARF nuclear prelamin A recognition factor
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NMRK1 nicotinamide riboside kinase 1
NPR3 natriuretic peptide receptor 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4D phosphodiesterase 4D, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PIR pirin (iron-binding nuclear protein)
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA2 paraneoplastic Ma antigen 2
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100P S100 calcium binding protein P
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG4 sperm associated antigen 4
SRGN serglycin
SST somatostatin
TAGLN2 transgelin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM47 transmembrane protein 47
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AIM1 absent in melanoma 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ATF5 activating transcription factor 5
B3GNT1
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
ESR1 estrogen receptor 1
GATA3 GATA binding protein 3
GRB14 growth factor receptor-bound protein 14
GREB1 growth regulation by estrogen in breast cancer 1
IL1RN interleukin 1 receptor antagonist
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT14 keratin 14, type I
LEF1 lymphoid enhancer-binding factor 1
MACF1 microtubule-actin crosslinking factor 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MGP matrix Gla protein
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MREG melanoregulin
PDLIM5 PDZ and LIM domain 5
PRAME preferentially expressed antigen in melanoma
PTN pleiotrophin
RBM47 RNA binding motif protein 47
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRPS1 trichorhinophalangeal syndrome I