BRD-K60866521_idelalisib_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K60866521_idelalisib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BCHE butyrylcholinesterase
BIN1 bridging integrator 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD69 CD69 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLCA1 chloride channel accessory 1
CLCA4 chloride channel accessory 4
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CTSW cathepsin W
CXCL10 chemokine (C-X-C motif) ligand 10
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EPHB2 EPH receptor B2
FAM3C family with sequence similarity 3, member C
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FERMT2 fermitin family member 2
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FXYD2 FXYD domain containing ion transport regulator 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPER1 G protein-coupled estrogen receptor 1
GRB10 growth factor receptor-bound protein 10
GSTA4 glutathione S-transferase alpha 4
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBEGF heparin-binding EGF-like growth factor
HOPX HOP homeobox
IGLL1 immunoglobulin lambda-like polypeptide 1
IGLV2-23 immunoglobulin lambda variable 2-23
IL18 interleukin 18
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIAA0125 KIAA0125
KLK11 kallikrein-related peptidase 11
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT6A keratin 6A, type II
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LMO4 LIM domain only 4
LTBP3 latent transforming growth factor beta binding protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METRN meteorin, glial cell differentiation regulator
MRPS30 mitochondrial ribosomal protein S30
MSRA methionine sulfoxide reductase A
MTMR11 myotubularin related protein 11
NDRG2 NDRG family member 2
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NKG7 natural killer cell granule protein 7
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDZK1 PDZ domain containing 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITX1 paired-like homeodomain 1
PLS1 plastin 1
PMP22 peripheral myelin protein 22
PPIC peptidylprolyl isomerase C (cyclophilin C)
PSD3 pleckstrin and Sec7 domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SATB2 SATB homeobox 2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SETBP1 SET binding protein 1
SIX2 SIX homeobox 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD7 SMAD family member 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFF3 trefoil factor 3 (intestinal)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TTN titin
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALB albumin
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
AZGP1 alpha-2-glycoprotein 1, zinc-binding
AZIN1 antizyme inhibitor 1
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CCNE2 cyclin E2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CECR1 cat eye syndrome chromosome region, candidate 1
CHGB chromogranin B
CLC Charcot-Leyden crystal galectin
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
ENOPH1 enolase-phosphatase 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERP44 endoplasmic reticulum protein 44
FGFR2 fibroblast growth factor receptor 2
FKBP5 FK506 binding protein 5
HIST1H2BG histone cluster 1, H2bg
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
LRRC41 leucine rich repeat containing 41
MMD monocyte to macrophage differentiation-associated
NEFH neurofilament, heavy polypeptide
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDIA3 protein disulfide isomerase family A, member 3
PEG10 paternally expressed 10
PPOX protoporphyrinogen oxidase
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
SERINC5 serine incorporator 5
SGCE sarcoglycan, epsilon
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMNDC1 survival motor neuron domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STEAP3 STEAP family member 3, metalloreductase
SYBU syntabulin (syntaxin-interacting)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TF transferrin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
THEMIS2 thymocyte selection associated family member 2
TMEM97 transmembrane protein 97
TRIM14 tripartite motif containing 14
TSPYL5 TSPY-like 5
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)