BRD-K60866521_idelalisib_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K60866521_idelalisib_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
AHNAK AHNAK nucleoprotein
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASRGL1 asparaginase like 1
BIK BCL2-interacting killer (apoptosis-inducing)
C1S complement component 1, s subcomponent
C3 complement component 3
CDKN2A cyclin-dependent kinase inhibitor 2A
CLU clusterin
CPM carboxypeptidase M
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENO2 enolase 2 (gamma, neuronal)
EPHB2 EPH receptor B2
F3 coagulation factor III (thromboplastin, tissue factor)
FGFR3 fibroblast growth factor receptor 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGLJ3 immunoglobulin lambda joining 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL32 interleukin 32
ITPK1 inositol-tetrakisphosphate 1-kinase
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
MUC5B mucin 5B, oligomeric mucus/gel-forming
PTGES prostaglandin E synthase
RPL38 ribosomal protein L38
SCLY selenocysteine lyase
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SSX1 synovial sarcoma, X breakpoint 1
STX1A syntaxin 1A (brain)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ANXA3 annexin A3
BST2 bone marrow stromal cell antigen 2
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
CTBS chitobiase, di-N-acetyl-
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
EDNRB endothelin receptor type B
FAM13A family with sequence similarity 13, member A
FGF13 fibroblast growth factor 13
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GMPR guanosine monophosphate reductase
GPM6B glycoprotein M6B
HAT1 histone acetyltransferase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGN3 high mobility group nucleosomal binding domain 3
HSPA1A heat shock 70kDa protein 1A
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
MAN1A1 mannosidase, alpha, class 1A, member 1
MSMO1 methylsterol monooxygenase 1
NEBL nebulette
NR1H2 nuclear receptor subfamily 1, group H, member 2
ODC1 ornithine decarboxylase 1
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PLN phospholamban
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
QKI QKI, KH domain containing, RNA binding
RRAGD Ras-related GTP binding D
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPHS1 selenophosphate synthetase 1
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STK26 serine/threonine protein kinase 26
TACSTD2 tumor-associated calcium signal transducer 2
TMSB15A thymosin beta 15a
TSPYL5 TSPY-like 5
TYRP1 tyrosinase-related protein 1
YME1L1 YME1-like 1 ATPase