BRD-K60476892_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K60476892_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
ATF3 activating transcription factor 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
EMP1 epithelial membrane protein 1
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GLA galactosidase, alpha
GSTT1 glutathione S-transferase theta 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
LMNA lamin A/C
MAOA monoamine oxidase A
MT1X metallothionein 1X
NT5E 5'-nucleotidase, ecto (CD73)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRNP prion protein
R3HDM4 R3H domain containing 4
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX9 SRY (sex determining region Y)-box 9
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VIM vimentin
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
C6ORF62 chromosome 6 open reading frame 62
CENPE centromere protein E, 312kDa
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CUX1 cut-like homeobox 1
DENND1B DENN/MADD domain containing 1B
EMP2 epithelial membrane protein 2
ESR1 estrogen receptor 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF14 kinesin family member 14
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MBNL1 muscleblind-like splicing regulator 1
MKL2 MKL/myocardin-like 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPPED2 metallophosphoesterase domain containing 2
NAV2 neuron navigator 2
NCALD neurocalcin delta
NCOA3 nuclear receptor coactivator 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
PAM peptidylglycine alpha-amidating monooxygenase
PCSK1 proprotein convertase subtilisin/kexin type 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMM2 phosphomannomutase 2
PRKCH protein kinase C, eta
PRSS23 protease, serine, 23
PTPRK protein tyrosine phosphatase, receptor type, K
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN2 regulator of calcineurin 2
RHOBTB3 Rho-related BTB domain containing 3
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAR steroidogenic acute regulatory protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
ZMYND8 zinc finger, MYND-type containing 8