BRD-K60476892_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

267 genes differentially expressed following the BRD-K60476892_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
ANXA4 annexin A4
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BGN biglycan
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL5 chemokine (C-C motif) ligand 5
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CKB creatine kinase, brain
CKM creatine kinase, muscle
CLC Charcot-Leyden crystal galectin
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXORF57 chromosome X open reading frame 57
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FST follistatin
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR87 G protein-coupled receptor 87
GPX1 glutathione peroxidase 1
GUSBP11 glucuronidase, beta pseudogene 11
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-F major histocompatibility complex, class I, F
HOPX HOP homeobox
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
INA internexin neuronal intermediate filament protein, alpha
IPO13 importin 13
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAG1 jagged 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMP3 lysosomal-associated membrane protein 3
LGALS1 lectin, galactoside-binding, soluble, 1
LRRC15 leucine rich repeat containing 15
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
NEB nebulin
NT5E 5'-nucleotidase, ecto (CD73)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPOX protoporphyrinogen oxidase
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTRF polymerase I and transcript release factor
RALGDS ral guanine nucleotide dissociation stimulator
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SDC3 syndecan 3
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SULF1 sulfatase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLMH bleomycin hydrolase
BMPR1A bone morphogenetic protein receptor, type IA
CA12 carbonic anhydrase XII
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNG1 cyclin G1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC123 cell division cycle 123
CDC42 cell division cycle 42
CDK19 cyclin-dependent kinase 19
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN3 claudin 3
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CNOT7 CCR4-NOT transcription complex, subunit 7
CXCL12 chemokine (C-X-C motif) ligand 12
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
ELOVL6 ELOVL fatty acid elongase 6
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FAM35A family with sequence similarity 35, member A
FOLR1 folate receptor 1 (adult)
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
GMDS GDP-mannose 4,6-dehydratase
GSPT1 G1 to S phase transition 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRX5 iroquois homeobox 5
JARID2 jumonji, AT rich interactive domain 2
KIAA0101 KIAA0101
KIAA0391 KIAA0391
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY6E lymphocyte antigen 6 complex, locus E
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEGF9 multiple EGF-like-domains 9
MELK maternal embryonic leucine zipper kinase
MLPH melanophilin
MSH6 mutS homolog 6
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAP1L1 nucleosome assembly protein 1-like 1
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NOTCH2 notch 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PBK PDZ binding kinase
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PITRM1 pitrilysin metallopeptidase 1
PLAC8 placenta-specific 8
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PLS1 plastin 1
PPA1 pyrophosphatase (inorganic) 1
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRC1 protein regulator of cytokinesis 1
PRKCB protein kinase C, beta
PROM1 prominin 1
PRSS23 protease, serine, 23
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
RBPMS RNA binding protein with multiple splicing
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC4 structural maintenance of chromosomes 4
SPDEF SAM pointed domain containing ETS transcription factor
SRP72 signal recognition particle 72kDa
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM9SF2 transmembrane 9 superfamily member 2
TMPO thymopoietin
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRIM37 tripartite motif containing 37
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE3C ubiquitin protein ligase E3C
UBL3 ubiquitin-like 3
UGCG UDP-glucose ceramide glucosyltransferase
VGLL4 vestigial-like family member 4
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMYM2 zinc finger, MYM-type 2