BRD-K60476892_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K60476892_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
CAST calpastatin
CCDC92 coiled-coil domain containing 92
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSTA cystatin A (stefin A)
CTSK cathepsin K
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP14 dual specificity phosphatase 14
DYNLT3 dynein, light chain, Tctex-type 3
EGR1 early growth response 1
EGR2 early growth response 2
EHF ets homologous factor
EIF5 eukaryotic translation initiation factor 5
FBP1 fructose-1,6-bisphosphatase 1
FOSL1 FOS-like antigen 1
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
IER2 immediate early response 2
IER3 immediate early response 3
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLPH melanophilin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NEBL nebulette
NMRK1 nicotinamide riboside kinase 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAF2 PRA1 domain family, member 2
RGCC regulator of cell cycle
RHOB ras homolog family member B
S100A10 S100 calcium binding protein A10
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
TGFA transforming growth factor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VIM vimentin
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ASPH aspartate beta-hydroxylase
BMPR1A bone morphogenetic protein receptor, type IA
CCNB1 cyclin B1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL9A3 collagen, type IX, alpha 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ENAH enabled homolog (Drosophila)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MAN1A1 mannosidase, alpha, class 1A, member 1
MTUS1 microtubule associated tumor suppressor 1
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PBX3 pre-B-cell leukemia homeobox 3
PLS3 plastin 3
PMM2 phosphomannomutase 2
PRC1 protein regulator of cytokinesis 1
PXMP2 peroxisomal membrane protein 2, 22kDa
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPRED2 sprouty-related, EVH1 domain containing 2
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
UGDH UDP-glucose 6-dehydrogenase